Name | Tr-PEG2-OH |
Synonyms | Tr-PEG3 Tr-PEG2-OH 2-(2-(trityloxy)ethoxy)ethanol 2-(2-(trityloxy)ethoxy)ethanol(WXPC0042) Ethanol, 2-[2-(triphenylmethoxy)ethoxy]- |
CAS | 105589-77-3 |
Molecular Formula | C23H24O3 |
Molar Mass | 348.43 |
Density | 1.127±0.06 g/cm3(Predicted) |
Boling Point | 481.9±40.0 °C(Predicted) |
pKa | 14.35±0.10(Predicted) |
Storage Condition | 室温,干燥,密封 |
MDL | MFCD17926568 |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
biological activity | Tr-PEG2-OH is a PROTAC linker belonging to the PEG class. Can be used for the synthesis of PROTAC molecules. Tr-PEG2-OH is also a non-cleavable ADC linker containing 2 units of PEG and can be used to synthesize antibody-conjugated drugs (ADC). |