2-(2-HYDROXYETHYL)THIOPHENE
2-(2-Thienyl)ethanol
CAS: 5402-55-1
Molecular Formula: C6H8OS
2-(2-HYDROXYETHYL)THIOPHENE - Names and Identifiers
2-(2-HYDROXYETHYL)THIOPHENE - Physico-chemical Properties
| Molecular Formula | C6H8OS |
| Molar Mass | 128.19 |
| Density | 1.153 g/mL at 25 °C (lit.) |
| Boling Point | 108-109 °C/13 mmHg (lit.) |
| Flash Point | 214°F |
| Water Solubility | slightly soluble |
| Vapor Presure | 0.0564mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear light yellow to gray-green or brownish |
| BRN | 106985 |
| pKa | 14.77±0.10(Predicted) |
| Storage Condition | Store below +30°C. |
| Refractive Index | n20/D 1.551(lit.) |
| MDL | MFCD00005462 |
| Physical and Chemical Properties | Density 1.153 refractive index 1.549-1.552 Flash Point 101 ° C water-soluble clear solution boiling point 108 ° C (13 mmHg) |
| Use | Used as an intermediate of Ticlopidine as an antithrombotic drug |
2-(2-HYDROXYETHYL)THIOPHENE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 3334 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 13 |
| TSCA | Yes |
| HS Code | 29349990 |
| Hazard Note | Irritant |
2-(2-HYDROXYETHYL)THIOPHENE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| traits | 2-thiophene ethanol is colorless or light yellow clear liquid. |
| introduction | 2-thiophene ethanol is a key intermediate for the preparation of clopidogrel, an antithrombotic drug, and is also a prerequisite drug for a variety of new anti-inflammatory and analgesic drugs. 2-thiophene ethanol and derivatives are the raw materials for the synthesis of 2-thiophene ethylamine. 2-thiophene ethylamine can be used in the synthesis of a variety of drugs. It is the preparation of a variety of cardiovascular diseases and anti-inflammatory and analgesic related to platelets and thrombosis. The key drug intermediates of new drugs, such as ticlopidine hydrochloride, clopidogrel bisulfate and prasugrel hydrochloride, which are important drugs for the synthesis of cardiovascular and cerebrovascular diseases. |
| Use | 2-thiophene ethanol is used as an antithrombotic drug ticlopidine intermediate. Pharmaceutical intermediates, organic synthesis intermediates. Used as an antithrombotic drug ticlopidine intermediate |
| preparation method | a synthesis method of 2-thiophene ethanol, the steps are as follows: thiophene and toluene are added into a reaction container with mechanical stirring, sodium hydride with mass concentration of 45% is added in batches, the temperature is raised to 40 ℃ for 4h, and ethylene oxide is introduced after the heat preservation is completed, the mass-volume ratio of thiophene, toluene, sodium hydride and ethylene oxide is 100g:280ml:65g:66g; Then keep the temperature for 10 hours. After the heat preservation, the reaction liquid is adjusted to ph = 1 with dilute hydrochloric acid with mass concentration of 8%, stratified, the organic layer is adjusted to ph = 7 with saturated sodium bicarbonate solution, stratified, the organic layer is washed with saturated salt water, and the organic layer is concentrated to dry under reduced pressure to obtain 2-thiophene ethanol. |
Last Update：2024-04-10 22:29:15
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