2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE - Names and Identifiers
2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE - Physico-chemical Properties
Molecular Formula | C9H8F2O2
|
Molar Mass | 186.16 |
Density | 1.298±0.06 g/cm3(Predicted) |
Boling Point | 228.1±40.0 °C(Predicted) |
Storage Condition | 2-8℃ |
2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE - Introduction
2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE is an organic compound with the formula C8H6F2O2. Its main properties include:
1. appearance: colorless liquid.
2. Melting point:-55°C.
3. Boiling point: 85-87°C.
4. Density: 1.30 g/mL.
5. solubility: soluble in common organic solvents, such as ethanol, ether and dichloromethane.
2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE is commonly used as a reagent in organic synthesis. It has high stability and reactivity and can be used to synthesize drugs, pesticides and chemical intermediates. It can be used as a substitution reagent for aromatic compounds to introduce difluorophenyl groups by a substitution reaction.
The method for preparing 2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE is usually carried out by substitution reaction. The commonly used methods are as follows:
1. 3, 4-difluorobenzoic acid and ethylene glycol are reacted under appropriate conditions to generate 2-(3,4-difluorophenyl)-1,3-dioxopentanoic acid, which is then esterified with anhydrous alcohol and acid catalyst to synthesize the target compound.
2. In the presence of an appropriate base catalyst, 1,3-dioxolane carbonate and 3,4-difluorophenyl bromide react to generate the target compound.
When using and handling 2-(3,4-DIFLUOROPHENYL)-1,3-DIOXOLANE, you need to pay attention to the following safety precautions:
1. Avoid contact with skin and inhalation of vapors, and wear appropriate personal protective equipment, such as protective gloves, safety glasses and protective masks.
2. Good laboratory safety measures should be observed during operation to ensure good ventilation.
3. The compound must not be discharged into the sewer or the environment, and should be treated and disposed of in accordance with local regulations.
Last Update:2024-04-09 19:05:53