2-(3,6-dihydro-2H-thiopyran-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
4,4,5,5-Tetramethyl-2-(tetrahydro-2H-thiopyran-4-yl)-1,3,2-dioxaborolane
CAS: 862129-81-5
Molecular Formula: C11H19BO2S
2-(3,6-dihydro-2H-thiopyran-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane - Names and Identifiers
2-(3,6-dihydro-2H-thiopyran-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane - Physico-chemical Properties
| Molecular Formula | C11H19BO2S |
| Molar Mass | 226.14 |
| Density | 1.04±0.1 g/cm3(Predicted) |
| Boling Point | 268.2±50.0 °C(Predicted) |
| Flash Point | 123.8°C |
| Vapor Presure | 0.0062mmHg at 25°C |
| Appearance | Solid |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.484 |
2-(3,6-dihydro-2H-thiopyran-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane - Reference Information
| Use | 3, 6-dihydro-2H-thian-4-borate Pinacol ester is an organic intermediate that can be used in Suzuki metal coupling reactions. |
| preparation | the first step: after mixing tetrahydropyridine/thian-4-one, p-toluenesulfonyl hydrazide and ethanol, heating reflux reaction, after the reaction is completed steaming to dry solvent, adding organic alkali and dichloromethane, adding NBS solution dropwise, after the detection reaction is complete, add hydrochloric acid aqueous solution to quench, separate out the organic layer, evaporate dry solvent at normal pressure, add sulfolane, and distill under reduced pressure to obtain alkenyl bromine intermediate with GC content above 98% and yield 73-78%; Step 2: Add metal magnesium and anhydrous ether solvent, drop methyl iodide to start adding alkenyl bromine, add reflux reaction to obtain Grignard reagent, then drop into trimethyl borate, after the reaction is complete, add hydrochloric acid aqueous solution to quench, add ethyl acetate and diol to the organic layer, stir until the reaction is complete at room temperature, wash with saturated salt in the organic layer, evaporate to dry the solvent, add n-heptane, cool to -10 ℃, filter to obtain solid 3, 6-dihydro-2H-thian-4-borate pinacol ester, GC and HNMR content above 98%, yield 62-66%. |
Last Update：2024-04-10 22:29:15
Supplier List
Product Name: 4,4,5,5-tetramethyl-2-(3,5-dihydro-2H-thiopyran-4-yl)-1,3,2-dioxaborolane Visit Supplier Webpage Request for quotation
CAS: 862129-81-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 862129-81-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 4,4,5,5-tetramethyl-2-(3,5-dihydro-2H-thiopyran-4-yl)-1,3,2-dioxaborolane Visit Supplier Webpage Request for quotation
CAS: 862129-81-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 862129-81-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History