2-(3-benzoylphenyl)-propionicaci
ketoprofen
CAS: 22071-15-4;22161-81-5
Molecular Formula: C16H14O3
2-(3-benzoylphenyl)-propionicaci - Names and Identifiers
| Name | ketoprofen |
| Synonyms | ORUDIS 19583rp ORUVAIL 19583 RP ketoprofen S)-ketoprofen Dexketoprofen S-(+)-Ketoprofen (S)-(+)-Ketoprofen (S)-(+)-ketoprofen RARECHEM AL BO 1306 M-BENZOYLHYDRATROPIC ACID 2-(3-benzoylphenyl)-propionicaci 2-(3-benzoylphenyl)propionic acid 2-(meta-benzoylphenyl) propionic acid (2S)-2-(3-benzoylphenyl)propanoic acid |
| CAS | 22071-15-4 22161-81-5 |
| EINECS | 244-759-8 |
| InChI | InChI=1/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1 |
| InChIKey | DKYWVDODHFEZIM-UHFFFAOYSA-N |
2-(3-benzoylphenyl)-propionicaci - Physico-chemical Properties
| Molecular Formula | C16H14O3 |
| Molar Mass | 254.29 |
| Density | 1.1565 (rough estimate) |
| Melting Point | 93-96°C |
| Boling Point | 357.5°C (rough estimate) |
| Flash Point | 228.793°C |
| Water Solubility | 209mg/L(room temperature) |
| Solubility | ethanol: 50 mg/mL. Easily soluble in methanol, soluble in ethanol, acetone or ether, almost insoluble in water. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Off-White |
| Merck | 14,5305 |
| pKa | pKa 5.94(MeOH/H2O) (Uncertain) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5600 (estimate) |
| MDL | MFCD00055790 |
| Physical and Chemical Properties | Melting point 93-96°C |
| Use | Anti-inflammatory analgesics, used in the treatment of rheumatoid arthritis, ankylosing spondylitis and gout and other diseases |
2-(3-benzoylphenyl)-propionicaci - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | UE7570000 |
| TSCA | Yes |
| HS Code | 29183000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 101 mg/kg (Ueno) |
2-(3-benzoylphenyl)-propionicaci - Reference
| Reference Show more | 1. [IF=7.514] Nan Zhang et al."Hydrophilic carboxyl supported immobilization of UiO-66 for novel bar sorptive extraction of non-steroidal anti-inflammatory drugs in food samples."Food Chem. 2021 Sep;355:129623 2. [IF=4.759] Yan Gao et al."Novel solid-phase extraction filter based on a zirconium meta-organic framework for determination of non-steroidal anti-inflammatory drugs residues."J Chromatogr A. 2021 Aug;1652:462349 3. [IF=3.535] Hui Jiang et al."Determination of lipid–water partition coefficient of neutral and ionic drugs by liposome electrokinetic chromatography."Electrophoresis. 2021 Aug;42(14-15):1436-1449 4. [IF=3.935] Hui Jiang et al."Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability."J Pharmaceut Biomed. 2022 Feb;209:114513 |
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