2-(4-METHYLPHENYL)ETHANOL
2-(4-METHYLPHENYL)ETHANOL
CAS: 699-02-5
Molecular Formula: C9H12O
2-(4-METHYLPHENYL)ETHANOL - Names and Identifiers
| Name | 2-(4-METHYLPHENYL)ETHANOL |
| Synonyms | 2-(P-TOLYL)ETHANOL 4-methyl-benzeneethano 4-Methylbenzeneethanol 4-methyl-Benzeneethanol 2-(4-METHYLPHENYL)ETHANOL 4-METHYLPHENETHYL ALCOHOL 2-(p-Methylphenyl)ethanol P-METHYLPHENETHYL ALCOHOL |
| CAS | 699-02-5 |
| EINECS | 211-824-7 |
| InChI | InChI=1/C9H12O/c1-8-2-4-9(5-3-8)6-7-10/h2-5,10H,6-7H2,1H3 |
2-(4-METHYLPHENYL)ETHANOL - Physico-chemical Properties
| Molecular Formula | C9H12O |
| Molar Mass | 136.19 |
| Density | 0.978g/mLat 25°C(lit.) |
| Boling Point | 244-245°C(lit.) |
| Flash Point | 225°F |
| Appearance | Solid |
| Specific Gravity | 0.978 |
| Color | Colorless to Light yellow to Light orange |
| pKa | 14.92±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.526(lit.) |
| MDL | MFCD00002904 |
2-(4-METHYLPHENYL)ETHANOL - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29062990 |
2-(4-METHYLPHENYL)ETHANOL - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | the liver and gallbladder can be produced by Swiss PHAFGAG company, and domestic import resumed in 2004. Liver and gallbladder can be compound tablets, each tablet containing 75.0mg α-naphthylacetic acid (α-naa) benzyl nicotinate 37.5mg. Which is an important component of benzyl ester, which is a kind of oily liquid can promote bile secretion and liver protection, can make the liver fat blood transport to the liver fat bank, it has a significant inhibitory effect on the destruction of liver cells caused by alcohol poisoning. |
| preparation | 1. For reduction of methyl acetophenone, weigh a certain amount of 4-methylacetophenone in a three-necked flask, add a certain amount of anhydrous ethanol, in an ice-water bath, add a certain amount of sodium borohydride with stirring, and react for 5-6 hours, the end point of the reaction was detected by thin layer chromatography, acidification, distillation, and the corresponding boiling point range fractions were collected. The 4-methyl-α-phenylethyl alcohol obtained was analyzed by gas chromatography to a purity of more than 96%. 2. Synthesis of benzyl nicotinate weigh a certain amount of nicotinic acid and pyridine into a three-necked flask, and slowly drop POCl3 under stirring. When POCl3 drops are finished, the water bath temperature is increased appropriately, and the reaction between niacin and POCl3 is completed, adding A certain amount of 4-methyl-α-phenylethyl alcohol for A certain time of reaction (adding A small amount of catalyst A, and continuing the reaction for A certain time. The pyridine was recovered under reduced pressure, the residue was poured into distilled water and allowed to stand. The mixture was separated into layers, and the pH was adjusted to make the system neutral. Wash with distilled water for 3-4 times and dry. 3. Purification of benzyl nicotinate dry hydrogen chloride gas was passed through the crude product with slow stirring. After completion of the reaction, it is filtered and washed 2-3 times with petroleum ether. The petroleum ether was evaporated under reduced pressure, dissolved with distilled water, and neutralized with sodium hydroxide solution dropwise. When the solution was neutral, the product was precipitated. The product was washed 4-5 times with distilled water and dried to calculate the yield. |
Last Update：2024-04-09 20:13:35
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Product Name: 4-methyl-benzeneethanol Visit Supplier Webpage Request for quotationCAS: 699-02-5
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Mobile: 18021002903
QQ: 3008007409
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