2-(4-oxo-1-piperidinyl)acetic acid tert-butyl ester

2-(4-oxo-1-piperidinyl)acetic acid tert-butyl ester - Names and Identifiers

Name	1-(Tert-Butoxycarbonylmethyl)-4-Piperidinone
Synonyms	tert-Butyl (4-oxopiperidin-1-yl)acetate tert-Butyl 2-(4-oxopiperidin-1-yl)acetate 1,1-Dimethylethyl 4-oxo-1-piperidineacetate 1-(TERT-BUTOXYCARBONYLMETHYL)-4-PIPERIDINONE 1-(Tert-Butoxycarbonylmethyl)-4-Piperidinone 2-(4-oxo-1-piperidinyl)acetic acid tert-butyl ester 1-Piperidineaceticacid, 4-oxo-, 1,1-dimethylethyl ester 1-Piperidineacetic acid, 4-oxo-, 1,1-dimethylethyl ester
CAS	149554-03-0

2-(4-oxo-1-piperidinyl)acetic acid tert-butyl ester - Physico-chemical Properties

Molecular Formula	C11H19NO3
Molar Mass	213.27
Density	1.060±0.06 g/cm3(Predicted)
Boling Point	308.1±27.0 °C(Predicted)
pKa	5.48±0.20(Predicted)
Storage Condition	2-8°C

2-(4-oxo-1-piperidinyl)acetic acid tert-butyl ester - Introduction

1-(Tert-Butoxycarbonylmethyl)-4-Piperidinone, also known as tert-butoxycarbonylpiperidine or TBOC-4-piperidone, is an organic compound. It has the following properties:

1. Appearance: colorless to light yellow crystal or powder.
2. Solubility: soluble in ethanol, ether and chlorinated hydrocarbons, slightly soluble in water.
3. Storage conditions: need to be stored in a dry, low temperature, dark place.

This compound is mainly used for the introduction and removal of protecting groups and functional groups in organic synthesis. Common uses include:

1. Protecting group: The selectivity of other active functional groups in the reaction can be protected by introducing TBOC group on the functional group.
2. Introduction of functional groups: TBOC-4-piperidone can be used as a lead for the synthesis of other organic compounds containing piperidine or ketone groups.
3. Chemical reaction intermediates: can be used as intermediates for some organic synthesis reactions, such as substrates for Amadori rearrangement reactions.

The method of preparing TBOC-4-piperidone is usually carried out by the following steps:

1.4-Piperidone is reacted with tert-butyl carbamate under basic conditions to generate 4-(tert-butoxypiperidin-1-yl)-3-piperidinamine.
2. Reaction of 4-(tert-butoxypiperidin-1-yl)-3-piperidinamine with carbon dioxide under high pressure conditions yields 1-(Tert-Butoxycarbonylmethyl)-4-Piperidinone.

Regarding safety information, the use of 1-(Tert-Butoxycarbonylmethyl)-4-Piperidinone should follow the following precautions:

1. Avoid contact with skin and eyes, such as accidental contact, please immediately rinse with plenty of water, and seek medical attention.
2. Use appropriate protective equipment during use, such as laboratory gloves, goggles and protective masks.
3. Storage should keep the container closed, away from the fire and oxidant.
4. Follow the site safety operation guidelines, such as explosion-proof and well-ventilated operation.
5. This compound is for professional use only and should follow laboratory safety regulations.

Please note that when using and handling chemicals, strictly abide by relevant safety operating procedures, and consult professionals according to the actual situation.

Last Update：2024-04-09 20:02:46