2-(Bromomagnesium)-5-chlorothiophene
5-Chloro-2-thienylmagnesium bromide
CAS: 111762-30-2
Molecular Formula: C4H2BrClMgS
2-(Bromomagnesium)-5-chlorothiophene - Names and Identifiers
2-(Bromomagnesium)-5-chlorothiophene - Physico-chemical Properties
| Molecular Formula | C4H2BrClMgS |
| Molar Mass | 221.79 |
| Density | 0.969 g/mL at 25 °C (lit.) |
| Boling Point | 65 °C (lit.) |
| Flash Point | 1°F |
| Appearance | Liquid |
| Color | Yellow to brown |
| Storage Condition | 2-8°C |
2-(Bromomagnesium)-5-chlorothiophene - Risk and Safety
| Risk Codes | R11 - Highly Flammable R14 - Reacts violently with water R19 - May form explosive peroxides R22 - Harmful if swallowed R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R37 - Irritating to the respiratory system R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S29 - Do not empty into drains. S8 - Keep container dry. |
| UN IDs | UN 2924 3/PG 2 |
| WGK Germany | 1 |
| HS Code | 29349990 |
2-(Bromomagnesium)-5-chlorothiophene - Introduction
bromide (bromide) is an organic compound with the chemical formula C4H3BrClMgS. It is a white crystal, soluble in ether and non-polar solvents. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
1. Appearance: white solid.
2. melting point: 50-55 ℃.
3. density: 1.39g/cm³.
4. Solubility: Soluble in ether, tetrahydrofuran and other non-polar solvents.
Use:
bromide is often used as a reagent in organic synthesis, especially as an intermediate of Grignard reagents in Grignard reactions. It can react with acylating agents, carboxylic acids, alcohols, etc. to produce the corresponding compounds.
Preparation Method:
The preparation of the bromide is generally based on the Grignard method:
1. First, react 5-chloro-2-thienyl bromide with excess magnesium in dry tetrahydrofuran to generate Grignard reagent (Grignard reagent):Mg 5-chloro-2-thienyl bromide → bromide.
2. Then, the synthesized Grignard reagent can be reacted with other reagents to generate the target compound.
Safety Information:
1. the bromide should be kept away from fire and stored in a dry and ventilated place.
2. Use the process should wear appropriate protective equipment, such as protective glasses, gloves and protective clothing.
3. Avoid inhaling its dust or solution, and avoid contact with skin and eyes.
4. For accidental contact or ingestion, please seek medical help immediately and show the safety data sheet of the compound.
Nature:
1. Appearance: white solid.
2. melting point: 50-55 ℃.
3. density: 1.39g/cm³.
4. Solubility: Soluble in ether, tetrahydrofuran and other non-polar solvents.
Use:
bromide is often used as a reagent in organic synthesis, especially as an intermediate of Grignard reagents in Grignard reactions. It can react with acylating agents, carboxylic acids, alcohols, etc. to produce the corresponding compounds.
Preparation Method:
The preparation of the bromide is generally based on the Grignard method:
1. First, react 5-chloro-2-thienyl bromide with excess magnesium in dry tetrahydrofuran to generate Grignard reagent (Grignard reagent):Mg 5-chloro-2-thienyl bromide → bromide.
2. Then, the synthesized Grignard reagent can be reacted with other reagents to generate the target compound.
Safety Information:
1. the bromide should be kept away from fire and stored in a dry and ventilated place.
2. Use the process should wear appropriate protective equipment, such as protective glasses, gloves and protective clothing.
3. Avoid inhaling its dust or solution, and avoid contact with skin and eyes.
4. For accidental contact or ingestion, please seek medical help immediately and show the safety data sheet of the compound.
Last Update：2024-04-10 22:29:15
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