2-(Bromomethyl)-4-nitroanisole

2-(Bromomethyl)-4-nitroanisole - Names and Identifiers

Name	2-(Bromomethyl)-4-nitroanisole
Synonyms	KOSHLAND II BRN 1878596 koshlandreagentno.2 Koshland's reagent II Koshland Reagent No. 2 2-BROMOMETHYL-4-NITROANISOLE 2-Bromomethyl-4-nitroanisole 2-(Bromomethyl)-4-nitroanisole 2-Methoxy-5-nitrobenzylbromide 2-(bromomethyl)-4-nitro-anisol 2-METHOXY-5-NITROBENZYL BROMIDE 2-Methoxy-5-nitrobenzyl bromide Anisole, 2-(bromomethyl)-4-nitro- alpha-bromo-2-methoxy-6-nitro-toluen Toluene, alpha-bromo-2-methoxy-6-nitro- 2-(bromomethyl)-1-methoxy-4-nitrobenzene 2-(bromomethyl)-1-methoxy-4-nitro-benzen Benzene, 2-(bromomethyl)-1-methoxy-4-nitro- 3-06-00-01276 (Beilstein Handbook Reference) 2-Bromomethyl-4-nitroanisole, Koshlands Reagent II
CAS	3913-23-3
EINECS	223-471-6
InChI	InChI=1/C8H8BrNO3/c1-13-8-3-2-7(10(11)12)4-6(8)5-9/h2-4H,5H2,1H3

2-(Bromomethyl)-4-nitroanisole - Physico-chemical Properties

Molecular Formula	C8H8BrNO3
Molar Mass	246.06
Density	1.589±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	76-78°C(lit.)
Boling Point	348.7°C at 760 mmHg
Flash Point	164.7°C
Vapor Presure	9.94E-05mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.588

2-(Bromomethyl)-4-nitroanisole - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3261 8/PG 2
WGK Germany	3
RTECS	XS7966500
FLUKA BRAND F CODES	19-21
Hazard Class	8
Packing Group	III

2-(Bromomethyl)-4-nitroanisole - Introduction

2-(Bromomethyl)-4-Nitroanisole is an organic compound with the chemical formula C8H8BrNO3. It is a yellow crystalline solid that is solid at room temperature. The following is a description of the properties, uses, preparation and safety information of this compound:

Nature:
-Appearance: Yellow crystalline solid
-Molecular weight: 243.06g/mol
-Melting Point: 89-91°C
-Boiling point: 309°C

Use:
2-(Bromomethyl)-4-nitroanisole is an important intermediate in organic synthesis. It is widely used in drug synthesis, especially for the synthesis of nitrogen mustard (a chemotherapy drug), doxorubicin (an anticancer drug), and some other drugs. In addition, it can also be used as a synthetic raw material for dyes and pigments.

Preparation Method:
The synthesis of 2-(Bromomethyl)-4-nitroanisole can be achieved by the following steps:
1. reacting anisole with methyl bromide to generate 2-bromomethyl anisole.
2.2-Bromomethyl anisole reacts with nitric acid to generate 2-(Bromomethyl)-4-nitroanisole.

Safety Information:
2-(Bromomethyl)-4-nitroanisole is an organic compound and should be handled with care. Here are some safety considerations:
-Avoid inhalation, contact with skin and ingestion.
-Wear appropriate protective equipment during operation, such as lab gloves, goggles and protective clothing.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice.
-Should be stored in a closed container, away from fire and oxidizing agents.
-Waste should be disposed of in accordance with local regulations and should not be dumped.

Last Update：2024-04-09 20:52:54