2-(Methylthio)-4-chloropyrimidine
4-Chloro-2-(methylthio)pyrimidine
CAS: 49844-90-8
Molecular Formula: C5H5ClN2S
2-(Methylthio)-4-chloropyrimidine - Names and Identifiers
| Name | 4-Chloro-2-(methylthio)pyrimidine |
| Synonyms | 4-Chloro-2-(Methylthio)py... 2-methylthio-4-chloropyrimine 4-Chloro-2-methylthiopyrimidine 2-(Methylthio)-4-chloropyrimidine 4-Chloro-2-(methylthio)pyrimidine 4-Chloro-2-methylsulfanyl-pyrimidine 4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE 4-Chloro-2-(methylmercapto)pyrimidine 4-chloro-2-(methylsulfanyl)pyrimidine |
| CAS | 49844-90-8 |
| EINECS | 256-500-6 |
| InChI | InChI=1/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3 |
| InChIKey | DFOHHQRGDOQMKG-UHFFFAOYSA-N |
2-(Methylthio)-4-chloropyrimidine - Physico-chemical Properties
| Molecular Formula | C5H5ClN2S |
| Molar Mass | 160.62 |
| Density | 1.381g/mLat 25°C(lit.) |
| Melting Point | −2°C(lit.) |
| Boling Point | 139-140°C36mm Hg(lit.) |
| Flash Point | >230°F |
| Water Solubility | Not miscible or difficult to mix in water. |
| Vapor Presure | 0.0511mmHg at 25°C |
| Appearance | liquid |
| BRN | 118042 |
| pKa | -0.56±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Hygroscopic |
| Refractive Index | n20/D 1.6(lit.) |
2-(Methylthio)-4-chloropyrimidine - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1760 8/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-13-23 |
| HS Code | 29335990 |
| Hazard Note | Corrosive/Hygroscopic |
| Hazard Class | 8 |
| Packing Group | III |
2-(Methylthio)-4-chloropyrimidine - Introduction
4-Chloro-2-(methylthio)pyrimidine is an organic compound with the chemical formula C5H5ClN2S. The following is a description of some of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to light yellow crystal or crystalline powder
-melting point: 58-61 ℃
-Boiling point: 250-252 ℃
-Density: 1.32g/cm³
-Soluble: Soluble in ethanol, ether, chloroform and dichloromethane, slightly soluble in water
Use:
4-Chloro-2-(methylthio)pyrimidine is an important synthetic intermediate, which is widely used in pesticide, medicine and organic synthesis. It is often used as a starting material for the preparation of pesticides, fungicides, antitumor drugs, antiviral drugs and other organic synthesis.
Preparation Method:
A commonly used preparation method is to react 2-mercapto-4-chloropyrimidine with methyl mercaptan. Specific reaction conditions can be optimized according to specific experimental requirements.
Safety Information:
- 4-Chloro-2-(methylthio)pyrimidine is irritating to the eyes, skin and respiratory tract, so use appropriate protective measures when exposed, such as wearing glasses and gloves, and avoiding inhalation of aerosols.
-During use, keep away from open flames and high temperatures to avoid harmful smoke and gases.
-When storing, keep 4-Chloro-2-(methylthio)pyrimidine in a dry, well-ventilated place away from fire and oxidizing agents.
-When handling this compound, follow proper laboratory practices and safe operating instructions.
Nature:
-Appearance: Colorless to light yellow crystal or crystalline powder
-melting point: 58-61 ℃
-Boiling point: 250-252 ℃
-Density: 1.32g/cm³
-Soluble: Soluble in ethanol, ether, chloroform and dichloromethane, slightly soluble in water
Use:
4-Chloro-2-(methylthio)pyrimidine is an important synthetic intermediate, which is widely used in pesticide, medicine and organic synthesis. It is often used as a starting material for the preparation of pesticides, fungicides, antitumor drugs, antiviral drugs and other organic synthesis.
Preparation Method:
A commonly used preparation method is to react 2-mercapto-4-chloropyrimidine with methyl mercaptan. Specific reaction conditions can be optimized according to specific experimental requirements.
Safety Information:
- 4-Chloro-2-(methylthio)pyrimidine is irritating to the eyes, skin and respiratory tract, so use appropriate protective measures when exposed, such as wearing glasses and gloves, and avoiding inhalation of aerosols.
-During use, keep away from open flames and high temperatures to avoid harmful smoke and gases.
-When storing, keep 4-Chloro-2-(methylthio)pyrimidine in a dry, well-ventilated place away from fire and oxidizing agents.
-When handling this compound, follow proper laboratory practices and safe operating instructions.
Last Update：2024-04-09 20:49:11
