2-(Thiazol-4-yl)
2-(1,3-thiazol-4-yl)acetic acid
CAS: 7504-44-1
Molecular Formula: C5H5NO2S
2-(Thiazol-4-yl) - Names and Identifiers
2-(Thiazol-4-yl) - Physico-chemical Properties
| Molecular Formula | C5H5NO2S |
| Molar Mass | 143.164 |
| Density | 1.437±0.06 g/cm3(Predicted) |
| Melting Point | 139 °C |
| Boling Point | 313.7±17.0 °C(Predicted) |
| pKa | 4.07±0.10(Predicted) |
| Storage Condition | 2-8℃ |
2-(Thiazol-4-yl) - Upstream Downstream Industry
| Raw Materials | 4-Thiazoleacetic acid, ethyl ester Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate Ethyl 2-amino-4-thiazoleacetate |
2-(Thiazol-4-yl) - Introduction
2-(1,3-thiazol-4-yl)acetic acid, also known as 2-(1,3-thiazol-4-yl)acetic acid, is an organic compound. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 2-(1,3-thiazol-4-yl)acetic acid is a colorless or pale yellow crystalline solid.
-Solubility: It can be dissolved in water, but also soluble in common organic solvents such as ethanol and ether.
-Stability: It is relatively stable under neutral and weakly acidic conditions, but may decompose under alkaline conditions.
Use:
-Pharmaceutical field: 2-(1,3-thiazol-4-yl)acetic acid is commonly used as an intermediate in drug synthesis. Because of its thiazole ring in the molecule, it plays an important role in the synthesis of antibacterial drugs and anticancer drugs.
-Agricultural field: 2-(1,3-thiazol-4-yl)acetic acid can also be used as a synthetic intermediate for pesticides.
Method:
Generally, 2-(1,3-thiazol-4-yl)acetic acid can be synthesized by the following steps:
1. First, acrylic acid and sodium hydrogen thiocyanate are reacted by heating to obtain 2-thiocyanoacetic acid.
2. Then, 2-thiocyanoacetic acid is reacted with chloroethanol under alkaline conditions to generate ethyl 4-chlorothioate.
3. Finally, by reacting the resulting ethyl 4-chlorothioate with sodium sulfide, 2-(1,3-thiazol-4-yl)acetic acid was obtained.
Safety Information:
- 2-(1,3-thiazol-4-yl)acetic acid should avoid contact with skin and eyes, and avoid inhaling its dust or gas.
-Good ventilation should be provided during use or storage to avoid fire sources and open flames.
-Please keep 2-(1,3-thiazol-4-yl)acetic acid properly and avoid contact with oxidizing agents and strong alkali substances.
-In case of exposure to the substance, immediately flush the affected area with plenty of water and seek medical assistance.
Nature:
-Appearance: 2-(1,3-thiazol-4-yl)acetic acid is a colorless or pale yellow crystalline solid.
-Solubility: It can be dissolved in water, but also soluble in common organic solvents such as ethanol and ether.
-Stability: It is relatively stable under neutral and weakly acidic conditions, but may decompose under alkaline conditions.
Use:
-Pharmaceutical field: 2-(1,3-thiazol-4-yl)acetic acid is commonly used as an intermediate in drug synthesis. Because of its thiazole ring in the molecule, it plays an important role in the synthesis of antibacterial drugs and anticancer drugs.
-Agricultural field: 2-(1,3-thiazol-4-yl)acetic acid can also be used as a synthetic intermediate for pesticides.
Method:
Generally, 2-(1,3-thiazol-4-yl)acetic acid can be synthesized by the following steps:
1. First, acrylic acid and sodium hydrogen thiocyanate are reacted by heating to obtain 2-thiocyanoacetic acid.
2. Then, 2-thiocyanoacetic acid is reacted with chloroethanol under alkaline conditions to generate ethyl 4-chlorothioate.
3. Finally, by reacting the resulting ethyl 4-chlorothioate with sodium sulfide, 2-(1,3-thiazol-4-yl)acetic acid was obtained.
Safety Information:
- 2-(1,3-thiazol-4-yl)acetic acid should avoid contact with skin and eyes, and avoid inhaling its dust or gas.
-Good ventilation should be provided during use or storage to avoid fire sources and open flames.
-Please keep 2-(1,3-thiazol-4-yl)acetic acid properly and avoid contact with oxidizing agents and strong alkali substances.
-In case of exposure to the substance, immediately flush the affected area with plenty of water and seek medical assistance.
Last Update：2024-04-09 21:01:54
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Product Name: 2-(4-Thiazolyl)acetic Acid Visit Supplier Webpage Request for quotation
CAS: 7504-44-1
Tel: 18301782025
Email: 3008007409@qq.com
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QQ: 3008007409
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CAS: 7504-44-1
Tel: 18301782025
Email: 3008007409@qq.com
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QQ: 3008007409
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View History
Raw Materials for 2-(Thiazol-4-yl)
4-Thiazoleacetic acid, ethyl ester
Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate
Ethyl 2-amino-4-thiazoleacetate
Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate
Ethyl 2-amino-4-thiazoleacetate