2-(TrifluoroMethyl)pyridin-4(1H)-one

2-(TrifluoroMethyl)pyridin-4(1H)-one - Names and Identifiers

Name	2-(trifluoromethyl)pyridin-4(1H)-one
Synonyms	BUTTPARK 18250-50 2-Trifluoromethylpyridin-4-ol 2-(TRIFLUOROMETHYL)PYRIDIN-4-OL 2-(trifluoromethyl)-4-Pyridinol 2-(Trifluoromethyl)pyridin-4-ol 4-Pyridinol, 2-(trifluoromethyl)- 2-(trifluoromethyl)pyridin-4(1H)-one 2-(Trifluoromethyl)pyridin-4-ol, 4-H 2-(TrifluoroMethyl)pyridin-4(1H)-one 4-Hydroxy-2-(trifluoromethyl)pyridine 2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE 2-(Trifluoromethyl)pyridin-4-ol, 4-Hydroxy-alpha,alpha,alpha-trifluoro-2-picoline
CAS	170886-13-2
InChI	InChI=1/C6H4F3NO/c7-6(8,9)5-3-4(11)1-2-10-5/h1-3H,(H,10,11)

2-(TrifluoroMethyl)pyridin-4(1H)-one - Physico-chemical Properties

Molecular Formula	C6H4F3NO
Molar Mass	163.1
Density	1.423
Melting Point	120.0 to 124.0 °C
Boling Point	324.4±37.0 °C(Predicted)
Flash Point	34.997°C
Vapor Presure	8.157mmHg at 25°C
Appearance	Powder
Color	Off-white
pKa	7.53±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.437

2-(TrifluoroMethyl)pyridin-4(1H)-one - Introduction

2-(trifluoromethyl) pyriridin -4(1H)-one () is an organic compound with the chemical formula C6H4F3NO. The following is an introduction to some of its properties, uses, formulation and safety information:

Nature:
-Appearance: Colorless liquid.
-Melting point: 13-14 ° C.
-Boiling point: 118 ° C.
-Density: 1.46 g/mL.
-Solubility: Soluble in some organic solvents, such as ethanol, ether and dichloromethane.

Use:
- 2-(trifluoromethyl)pyridin-4(1H)-one is commonly used as an intermediate in organic synthesis. It can be used to synthesize various drugs, pesticides, dyes and other organic compounds.
-It can also be used as a ligand of the catalyst to participate in the catalysis of organic synthesis reactions.

Method:
2-(trifluoromethyl)pyridin-4(1H)-one can be synthesized by the following steps:
1. 2-pyridinecarboxylic acid reacts with trifluoromethyl chloride (CF3Cl) under basic conditions to give 2-trifluoromethyl-4-pyridinecarboxylic acid.
2. Use acid hydrolysis or reduction reaction to convert 2-trifluoromethyl-4-picolinic acid into 2-(trifluoromethyl)pyridin-4(1H)-one.

Safety Information:
- 2-(trifluoromethyl)pyridin-4(1H)-one has low toxicity, but it is still necessary to pay attention to safe operation and comply with relevant laboratory operation specifications and personal protective measures.
-Avoid contact with skin, eyes or respiratory tract to avoid irritation or injury.
-Good ventilation conditions should be maintained during use to prevent the accumulation of gas or steam.
-Avoid contact with strong oxidants and acids during storage and handling to prevent possible dangerous reactions.
-When handling this compound, local safety regulations and regulations should be observed.

Last Update：2024-04-09 02:00:43