2-(Trifluoromethyl)phenylalanine

2-(Trifluoromethyl)phenylalanine - Names and Identifiers

Name	2-(trifluoromethyl)phenylalanine
Synonyms	H-PHE(2-CF 3)-OH RARECHEM BK PT 0127 L-2-TRIFLUOROMETHYLPHE H-L-PHE(2-TRIFLUOROMETHYL)-OH 2-(trifluoromethyl)phenylalanine 2-(Trifluoromethyl)phenylalanine O-TRIFLUOROMETHYL-L-PHENYLALANINE 2-Trifluoromethyl-DL-phenylalanine 2-(Trifluoromethyl)-dl-phenylalanine 2-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid (S)-2-AMINO-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
CAS	3832-73-3
InChI	InChI=1/C10H10F3NO2/c11-10(12,13)7-4-2-1-3-6(7)5-8(14)9(15)16/h1-4,8H,5,14H2,(H,15,16)

2-(Trifluoromethyl)phenylalanine - Physico-chemical Properties

Molecular Formula	C10H10F3NO2
Molar Mass	233.19
Density	1.364g/cm³
Boling Point	299.4°C at 760 mmHg
Flash Point	134.9°C
Vapor Presure	0.000532mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.502

2-(Trifluoromethyl)phenylalanine - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
Hazard Note	Toxic
Hazard Class	IRRITANT-HARMFUL

2-(Trifluoromethyl)phenylalanine - Introduction

2-(trifluoromethyl)phenylalanine is an organic compound whose chemical formula is C9H9F3NO2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White crystalline powder.
-Solubility: Low solubility in water, soluble in organic solvents such as methanol, ethanol and acid.
-Melting point: about 165-170°C.
- pH: neutral or slightly acidic.

Use:
2-(trifluoromethyl)phenylalanine is usually used as an important raw material for pharmaceutical intermediates or synthesis of organic compounds. Its application areas include:
-Preparation of drugs: Because its structure contains the amino acid phenylalanine, it can be used as a key intermediate in drug synthesis and used to prepare a variety of drugs, such as antiviral drugs, anti-cancer drugs and immunomodulators.
-Chemical research: In organic synthesis, it can be used as a useful amino acid derivative for the construction of polypeptide chains and drug molecules.
-Medical applications: Studies have also shown that this compound may have inhibitory virus and anti-tumor effects.

Preparation Method: There are many ways to prepare
2-(trifluoromethyl)phenylalanine. The following is a common synthesis method:
2-trifluoromethyl-DL-phenylpropanoyl chloride was generated by reacting phenylacetyl chloride with ethyl trifluoromethylformate under base catalysis. This is then reacted with glycine in an alkaline solution to give 2-(trifluoromethyl)phenylalanine.

Safety Information:
- 2-(trifluoromethyl)phenylalanine are chemically considered to be relatively safe compounds.
-It needs to be stored in a dry, low-temperature environment to avoid contact with oxygen and moisture.
-Wear appropriate personal protective equipment such as gloves, goggles and laboratory tops when using or handling the compound.
-In any case, laboratory safety procedures should be followed to avoid direct contact with the skin and inhalation of dust from the compound.
-If touched or swallowed, wash the affected area immediately and seek medical help.
-There is no clear toxicity data, so care should be taken in use and handling.

Last Update：2024-04-09 20:49:11