2-(Trifluoromethyl)pyrrolidine

2-(Trifluoromethyl)pyrrolidine - Names and Identifiers

Name	2-(Trifluoromethyl)pyrrolidine
Synonyms	2-(TRIFLUOROMETHYL)PYRROLIDINE 2-(Trifluoromethyl)pyrrolidine DL-2-Trifluoromethylpyrrolidine 2-(Trifluoromethyl)-pyrrolidine DL-2-TRIFLUOROMETHYLPYRROLIDINE Pyrrolidine, 2-(trifluoromethyl)- (2R)-2-(trifluoromethyl)pyrrolidine 2(R)-2-(Trifluoromethyl)pyrrolidine 1-Aza-2-(trifluoromethyl)cyclopentane (R)-(-)-2-(Trifluoromethyl)PYRROLIDINE (R)-1-cyclopentyl-2,2,2-trifluoroethanamine 1,1'-(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)bis(4-methylbenzene)
CAS	119618-29-0 109074-67-1
InChI	InChI=1/C5H8F3N/c6-5(7,8)4-2-1-3-9-4/h4,9H,1-3H2/t4-/m1/s1

2-(Trifluoromethyl)pyrrolidine - Physico-chemical Properties

Molecular Formula	C5H8F3N
Molar Mass	139.12
Density	1.210g/mLat 25°C
Melting Point	29-33
Boling Point	104-106°C
Flash Point	78°F
Vapor Presure	60.3mmHg at 25°C
Storage Condition	2-8°C
Sensitive	Air Sensitive
Refractive Index	n20/D 1.379
MDL	MFCD02663405

2-(Trifluoromethyl)pyrrolidine - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms R11 - Highly Flammable
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S16 - Keep away from sources of ignition.
UN IDs	UN 1993 3/PG 3
WGK Germany	3
HS Code	29339900
Hazard Note	Flammable/Harmful
Hazard Class	4.1
Packing Group	III

2-(Trifluoromethyl)pyrrolidine - Introduction

2-(Trifluoromethyl) pyrrolidine is an organic compound with the chemical formula C5HF3N. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: 2-(Trifluoromethyl) pyrrolidine is a colorless to pale yellow liquid.
-melting point: about -87 ℃
-Boiling point: about 36-38 ℃
-Density: about 1.47g/cm³
-relative molecular mass: 129.06g/mol
-Solubility: 2-(Trifluoromethyl) pyrrolidine is soluble in common organic solvents such as ethanol, acetone and dimethyl sulfoxide.

Use:
-As a solvent: 2-(Trifluoromethyl) pyrrolidine is a commonly used organic solvent that can be used to dissolve and dilute some chemicals.
-Reagent in chemical reactions: The compound can be used as a reagent for some organic synthesis reactions, such as alkylation reactions, electrophilic substitution and fluorination reactions.

Preparation Method:
2-(trifluoromethyl) pyrrolidine has many preparation methods. The following is one of the commonly used methods:
-Reaction of pyrrolidine with trifluoromethyl thiourea under basic conditions to produce 2-(trifluoromethyl) pyrrolidine.

Safety Information:
Due to the high safety of 2-(trifluoromethyl) pyrrolidine, there is no report that it causes obvious harm to human health or the environment. However, as an organic solvent, it still has some general hazards of common organic solvents, such as skin irritation and eye irritation. When using this compound, appropriate laboratory safety measures should be taken, including the use of gloves, safety glasses and ventilation facilities. After contact with skin or eyes, rinse with water immediately and seek medical attention in severe cases. When using or handling the compound, care should be taken to avoid inhalation of its vapors or contact with its liquids. Storage should be sealed and stored in a cool, dry place, away from fire and oxidant.

Last Update：2024-04-10 22:29:15