2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride
tripelennamine hydrochloride
CAS: 154-69-8
Molecular Formula: C16H22ClN3
2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride - Names and Identifiers
| Name | tripelennamine hydrochloride |
| Synonyms | Ahistamin Tripelennamine HCl Antiallergicum medivet tripelennamine hydrochloride N-benzyl-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinhydrochloride 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride 2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-, hydrochloride 2-ethanediamine,n,n-dimethyl-n'-(phenylmethyl)-n'-2-pyridinyl-monohydroc 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride |
| CAS | 154-69-8 |
| EINECS | 205-833-5 |
| InChI | InChI=1/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H |
2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride - Physico-chemical Properties
| Molecular Formula | C16H22ClN3 |
| Molar Mass | 291.82 |
| Density | 1.20 |
| Melting Point | 192-193℃ |
| Boling Point | 387.8°C at 760 mmHg |
| Flash Point | 188.3°C |
| Solubility | Soluble in methanol, water |
| Vapor Presure | 3.21E-06mmHg at 25°C |
| Appearance | White solid |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD00012815 |
| In vitro study | Tripelennamine is a substrate of a tertiary amine UDP glucuronosyltransferase enzyme that catalyzes the formation of quaternary ammonium-linked glucoglycinate. In human and rabbit liver microsomes, Tripelennamine can inhibit [4,5-b] pyrimidine (PhIP) glycolipidation, inhibition of both competitive and non-competitive inhibition. Compared to the vibrational mode of a completely neutral molecule in alkaline solution, the vibrational mode of the Tripelennamine aminopyridine chromophore at neutral pH is modified, when the alkyl chain is protonated. |
| In vivo study | Tripleennamine HCl (intravenous injection) causes the central nervous system of standing horses to become very alert, anxious and uncomfortable, they lift their heads and tighten their neck muscles with excessive rapid movement of eyes and ears, biting, sucking, rapidly waving their tails and stamping their forelimbs, and turning over the ground. The hemoglobin concentration of standing horses increased significantly after tripleennamine HCl treatment. Tripleennamine HCl (intravenous) significantly increased the mixed venous blood O 2 pressure and hemoglobin-O 2 saturation in standing horses, while increasing the O 2 content in arterial and mixed venous blood, but the gradient of O 2 concentration in arterial to mixed venous blood was not significantly affected. Tripleennamine HCl (0.5 mg/kg I. V.) had terminal elimination half-lives of 2.39 and 2.08 H in horses and camels, respectively, and total body clearance rates of 0.97 and 0.84 L/h/kg, respectively. The steady-state distribution volumes were 2.87 and 1.69 L/kg, respectively, and the central compartment volumes in these two pharmacokinetic models were 1.75 and 1.06 L/kg, respectively. |
2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | US3150000 |
| HS Code | 2933399090 |
| Toxicity | LD50 in mice (mg/kg): 47 i.p. (Walker) |
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