2-(bromomethyl)-1-chloro-4-fluorobenzene

2-(bromomethyl)-1-chloro-4-fluorobenzene - Names and Identifiers

Name	2-Chloro-5-fluorobenzyl bromide
Synonyms	2-Chloro-5-fluoroben 2-Chloro-5-fluorobenzyl bromide 2-CHLORO-5-FLUOROBENZYL BROMIDE 2-Chloride-5-Fluoride Bromine Benzyl 2-(bromomethyl)-1-chloro-4-fluorobenzene 2-(broMoMethyl)-1-chloro-4-fluorobenzene 1-(Bromomethyl)-2-chloro-5-fluorobenzene 1-[bromo(difluoro)methoxy]-4-nitrobenzene Benzene, 2-(bromomethyl)-1-chloro-4-fluoro-
CAS	81778-09-8
InChI	InChI=1/C7H5BrClF/c8-4-5-3-6(10)1-2-7(5)9/h1-3H,4H2

2-(bromomethyl)-1-chloro-4-fluorobenzene - Physico-chemical Properties

Molecular Formula	C7H5BrClF
Molar Mass	223.47
Density	1.654 g/mL at 25 °C (lit.)
Boling Point	65-66 °C/2 mmHg (lit.)
Flash Point	18°C
Vapor Presure	0.141mmHg at 25°C
Appearance	Liquid
Color	Colorless
Storage Condition	2-8℃
Sensitive	Lachrymatory
Refractive Index	n20/D 1.566(lit.)
MDL	MFCD01631419

2-(bromomethyl)-1-chloro-4-fluorobenzene - Risk and Safety

Risk Codes	R11 - Highly Flammable R34 - Causes burns R45 - May cause cancer R36/37/39 - R33 - Danger of cumulative effects R26 - Very Toxic by inhalation R23 - Toxic by inhalation R16 - Explosive when mixed with oxidizing substances
Safety Description	S16 - Keep away from sources of ignition. S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S34 - S11 -
UN IDs	UN 2924 3/PG 1
WGK Germany	3
HS Code	29039990
Hazard Note	Corrosive/Lachrymatory
Hazard Class	3
Packing Group	II

2-(bromomethyl)-1-chloro-4-fluorobenzene - Introduction

2-Chloro-5-fluorobenzyl bromide is an organic compound with the chemical formula C7H5BrClF.

Nature:
-Appearance: colorless liquid
-Melting point:-24 ℃
-Boiling point: 98-100 ℃
-Density: 1.65g/cm3
-Solubility: Soluble in organic solvents such as alcohols and ethers

Use:
2-Chloro-5-fluorobenzyl bromide can be used in organic synthesis reaction, is a kind of alkylation reagent and halogen reagent. It is often used in the preparation of aromatic ether compounds, pharmaceutical and pesticide intermediates.

Preparation Method:
2-Chloro-5-fluorobenzyl bromide can be prepared by the following steps:
-First, 2-chloro-5-fluorobenzene is reacted with sodium bromate to obtain 2-chloro-5-fluorobenzoic acid.
-Then react 2-chloro-5-fluorobenzoic acid with brominated sulfoxide to obtain 2-chloro-5-fluorobenzoic acid sulfoxide.
-Finally, 2-chloro-5-fluorobenzoic acid sulfoxide ester is reacted with thionyl chloride to obtain 2-Chloro-5-fluorobenzyl bromide.

Safety Information:
2-Chloro-5-fluorobenzyl bromide is an organic bromine compound and should be subject to general laboratory safety practices. It is irritating and toxic and should avoid contact with skin, eyes and respiratory tract. Appropriate personal protective equipment such as gloves, safety glasses and face shields should be worn during operation.

Last Update：2024-04-09 02:00:48