2-(chloromethyl)-1,3-benzoxazole

2-(chloromethyl)-1,3-benzoxazole - Names and Identifiers

Name	2-(chloromethyl)-1,3-benzoxazole
Synonyms	2-CHLOROMETHYLBENZOXAZOLE 2-Chloromethyl-benzooxazole Benzoxazole, 2-(chloroMethyl)- benzoxazole, 2-(chloromethyl)- 2-(CHLOROMETHYL)BENZO[D]OXAZOLE 2-(chlormethyl)-1,3-benzoxazole 2-(CHLOROMETHYL)-1,3-BENZOXAZOLE 2-(chloromethyl)-1,3-benzoxazole
CAS	41014-43-1
InChI	InChI=1/C8H6ClNO/c9-5-8-10-6-3-1-2-4-7(6)11-8/h1-4H,5H2

2-(chloromethyl)-1,3-benzoxazole - Physico-chemical Properties

Molecular Formula	C8H6ClNO
Molar Mass	167.59
Density	1.316±0.06 g/cm3(Predicted)
Boling Point	75/0.15mm
Flash Point	98.2°C
Vapor Presure	0.0644mmHg at 25°C
pKa	0.95±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.612

2-(chloromethyl)-1,3-benzoxazole - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	43 - May cause sensitization by skin contact
Safety Description	36/37 - Wear suitable protective clothing and gloves.
Hazard Class	IRRITANT

2-(chloromethyl)-1,3-benzoxazole - Introduction

2-(chloromethyl)-1,3-benzoxazole is an organic compound with the formula C8H6ClNO, which contains a chloromethyl group and a benzoxazole ring. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 2-(chloromethyl)-1,3-benzoxazole is a white crystalline solid.
-Melting point: about 60-62°C.
-Boiling point: about 228°C.
-Solubility: It is soluble in organic solvents such as ethanol, dichloromethane and dimethylformamide.

Use:
2-(chloromethyl)-1,3-benzoxazole can be used as a reagent and intermediate in organic synthesis. Its main uses include:
-As an important intermediate in organic synthesis, it plays a key role in the synthesis of various organic compounds.
-Used to prepare compounds with fluorescent activity, which can be used in the fields of luminescent materials, fluorescent indicators and optical sensors.

Preparation Method:
A commonly used synthesis method is to react 2-oxalyl benzoxazole (2-formyl-Benzoxazole) with methyl chloride to generate 2-(chloromethyl)-1,3-benzoxazole. The specific synthesis step is that 2-oxalyl benzoxazole and chloroform (chloroform) are reacted in the presence of a base, and the target product is obtained by acidification.

Safety Information:
- 2-(chloromethyl)-1,3-benzoxazole should comply with safety procedures during operation.
-It is an organic compound, so avoid prolonged contact with the skin and inhalation of its vapors or dust. Wear appropriate protective gloves, glasses and protective face mask during operation.
-During storage and transportation, 2-(chloromethyl)-1,3-benzoxazole should be stored in a sealed container, away from fire and oxidizing agents.
-If the compound is accidentally taken or exposed to it, seek medical advice immediately and provide the relevant safety data sheet.

Last Update：2024-04-10 22:29:15