2-(chloromethyl)-5-methyl-1,3,4-oxadiazole

2-(chloromethyl)-5-methyl-1,3,4-oxadiazole - Names and Identifiers

Name	2-(chloromethyl)-5-methyl-1,3,4-oxadiazole
Synonyms	2-Methyl-5-chloroMethyl-1,3,4-oxadiazole 5-(ChloroMethyl)-2-Methyl-1,3,4-oxadiazole 2-(chloromethyl)-5-methyl-1,3,4-oxadiazole 2-(CHLOROMETHYL)-5-METHYL-1,3,4-OXADIAZOLE 2-(Chloromethyl)-5-methyl-1,3,4-oxadiazole 1,3,4-Oxadiazole, 2-(chloromethyl)-5-methyl- 1,3,4-oxadiazole, 2-(chloromethyl)-5-methyl-
CAS	3914-42-9
InChI	InChI=1/C4H5ClN2O/c1-3-6-7-4(2-5)8-3/h2H2,1H3

2-(chloromethyl)-5-methyl-1,3,4-oxadiazole - Physico-chemical Properties

Molecular Formula	C4H5ClN2O
Molar Mass	132.55
Density	1.291±0.06 g/cm3(Predicted)
Melting Point	135-137 °C
Boling Point	211.7±42.0 °C(Predicted)
Flash Point	81.815°C
Vapor Presure	0.262mmHg at 25°C
pKa	-4.20±0.32(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.483

2-(chloromethyl)-5-methyl-1,3,4-oxadiazole - Risk and Safety

UN IDs	UN2811
Hazard Class	IRRITANT

2-(chloromethyl)-5-methyl-1,3,4-oxadiazole - Introduction

2-(chloromethyl)-5-methyl-1,3,4-oxadiazole is a five-membered heterocyclic compound containing chloromethyl and methyl groups. Its chemical formula is C4H5ClN2O and its molecular weight is 120.55g/mol.

The following are some properties of 2-(chloromethyl)-5-methyl-1,3,4-oxadiazole:
-Appearance: Colorless or light yellow crystal
-Melting point: 57-59 degrees Celsius
-Boiling point: 284 degrees Celsius
-Density: 1.42 g/ml
-Solubility: Good solubility in common organic solvents (such as ether, chloroform, benzene)

2-(chloromethyl)-5-methyl-1,3,4-oxadiazole has antibacterial and antifungal activities, so it has certain applications in the pharmaceutical and pesticide industries. It can be used as an intermediate in the synthesis of biologically active compounds.

A common method for preparing 2-(chloromethyl)-5-methyl-1,3,4-oxadiazole is by reacting 2-chloroacetaldehyde with an ammonia salt under alkaline conditions. The specific process includes the following steps:
1.2-chloroacetaldehyde and ammonia salt are reacted in alkaline solution to generate the intermediate of 2-(chloromethyl)-5-methyl-1,3,4-oxadiazole.
2. intermediate through acidification, crystallization and purification steps to obtain the target product.

When using 2-(chloromethyl)-5-methyl-1,3,4-oxadiazole, you need to pay attention to the following safety information:
-The compound is irritating and corrosive, and contact with skin and eyes can cause irritation and burns. Wear protective gloves, goggles and protective clothing when using.
-Avoid contact with strong oxidants to avoid fire or explosion.
-Maintain a well-ventilated environment during storage and handling, and avoid inhaling the dust or vapor of the compound.
-If the compound is swallowed or inhaled, seek medical attention immediately and provide the packaging or label to medical personnel for reference.

In summary, 2-(chloromethyl)-5-methyl-1,3,4-oxadiazole is a useful compound with antibacterial and antifungal activities, and can be used to synthesize other biologically active compounds. Pay attention to safe operation during use and follow relevant safety regulations.

Last Update：2024-04-09 21:32:40