2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid
Cyclopentolate Hydrochloride
CAS: 5870-29-1
Molecular Formula: C17H26ClNO3
2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid - Names and Identifiers
2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid - Physico-chemical Properties
| Molecular Formula | C17H26ClNO3 |
| Molar Mass | 327.85 |
| Melting Point | 137-141° |
| Solubility | Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9). |
| Appearance | neat |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Room Temperature |
2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid - Risk and Safety
| WGK Germany | 2 |
| RTECS | GY2450000 |
| HS Code | 2922190900 |
2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid - Use
Open Data Verified Data
| mydriasis and paralysis of the ciliary muscle. For eye drop formulations. |
Last Update：2024-01-02 23:10:35
2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid - Reference Information
| biological activity | Cyclopentolate is a muscarinic acetylcholine receptor antagonist, the Ki values for the M2 and M3 receptors are 1.62, 27.5 and 2.63 nM, respectively. |
| Target | Value |
| M1 receptor (Cell-free assay) | 1.62 nM(Ki) |
| M3 receptor (Cell-free assay) | 2.63 nM(Ki) |
| M2 receptor (Cell-free assay) | 27.5 nM(Ki) |
| Animal Model: | Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide (OP) poisoning model) |
| Dosage: | 20 mg/kg (Ophthalmic cyclopentolate) |
| Administration: | i.p. |
| Result: | Survival in rats pretreated with ophthalmic cyclopentolate (20 mg/kg) is 90%. |
Last Update：2024-04-10 22:29:15
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