2-(p-tolylsulfonyl)-1,2,3,4-Tetrahydro-isoquinoline
2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS: 20335-69-7
Molecular Formula: C16H17NO2S
2-(p-tolylsulfonyl)-1,2,3,4-Tetrahydro-isoquinoline - Names and Identifiers
| Name | 2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline |
| Synonyms | 1,2,3,4-Tetrahydro-2-(p-tolylsulfonyl)isoquinoline 2-(p-tolylsulfonyl)-1,2,3,4-Tetrahydro-isoquinoline 2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline Isoquinoline, 1,2,3,4-tetrahydro-2-[(4-methylphenyl)sulfonyl]- |
| CAS | 20335-69-7 |
| InChI | InChI=1/C16H17NO2S/c1-13-6-8-16(9-7-13)20(18,19)17-11-10-14-4-2-3-5-15(14)12-17/h2-9H,10-12H2,1H3 |
2-(p-tolylsulfonyl)-1,2,3,4-Tetrahydro-isoquinoline - Physico-chemical Properties
| Molecular Formula | C16H17NO2S |
| Molar Mass | 287.38 |
| Density | 1.244g/cm3 |
| Boling Point | 451.2°C at 760 mmHg |
| Flash Point | 226.7°C |
| Vapor Presure | 2.47E-08mmHg at 25°C |
| Refractive Index | 1.615 |
2-(p-tolylsulfonyl)-1,2,3,4-Tetrahydro-isoquinoline - Introduction
2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline, also known as PTSI, is a reagent commonly used in organic synthesis. Its chemical formula is C10H15NO3S and its molecular weight is 229.29g/mol. The following details of its nature, use, preparation and safety information.
Nature:
-Appearance: PTSI is white crystalline powder.
-Melting point: about 112-115 ° C.
-Solubility: PTSI is soluble in some organic solvents, such as dimethylformamide (DMF), dichloromethane and chloroform.
Use:
- PTSI can be used as a catalyst in hydrogenation reactions, and is often used to catalyze the hydrogenation reduction reaction of unsaturated compounds.
-It can also be used to synthesize various nitrogen-containing compounds, such as thiophene, benzothiophene and other derivatives.
- PTSI can also catalyze the oxidation of aromatic hydrocarbons in organic reactions, such as the oxidation of resorcinol.
Method:
The preparation of PTSI can usually be carried out by the following steps:
1. Synthesis of 2-p-Toluenesulfonyl -1,2,3,4-tetrahydroquinoline:
-Dissolve p-toluenesulfonic acid and isoquinoline in a suitable solvent, such as acetonitrile.
-At low temperature, slowly add silver nitrite solution dropwise.
-After the reaction is completed, the product is purified by crystallization to obtain 2-p-toluenesulfonyl-1, 2,3, 4-tetrahydroquinoline.
2.2-p-toluenesulfonyl-1, 2,3, 4-tetrahydroquinoline was used as a catalyst in the organic reaction.
Safety Information:
- PTSI has low toxicity, but it is still an organic substance, so you should follow safe operating procedures when using and storing it.
-During operation, try to avoid contact with skin and eyes, and wear personal protective equipment when using.
-If contact or ingestion occurs, rinse immediately with plenty of water and seek medical emergency.
- PTSI should be stored in a dry, cool, well-ventilated place, away from fire and oxidizing agents.
-When disposing of waste, it is necessary to follow local regulations and dispose of waste properly to prevent pollution to the environment.
Nature:
-Appearance: PTSI is white crystalline powder.
-Melting point: about 112-115 ° C.
-Solubility: PTSI is soluble in some organic solvents, such as dimethylformamide (DMF), dichloromethane and chloroform.
Use:
- PTSI can be used as a catalyst in hydrogenation reactions, and is often used to catalyze the hydrogenation reduction reaction of unsaturated compounds.
-It can also be used to synthesize various nitrogen-containing compounds, such as thiophene, benzothiophene and other derivatives.
- PTSI can also catalyze the oxidation of aromatic hydrocarbons in organic reactions, such as the oxidation of resorcinol.
Method:
The preparation of PTSI can usually be carried out by the following steps:
1. Synthesis of 2-p-Toluenesulfonyl -1,2,3,4-tetrahydroquinoline:
-Dissolve p-toluenesulfonic acid and isoquinoline in a suitable solvent, such as acetonitrile.
-At low temperature, slowly add silver nitrite solution dropwise.
-After the reaction is completed, the product is purified by crystallization to obtain 2-p-toluenesulfonyl-1, 2,3, 4-tetrahydroquinoline.
2.2-p-toluenesulfonyl-1, 2,3, 4-tetrahydroquinoline was used as a catalyst in the organic reaction.
Safety Information:
- PTSI has low toxicity, but it is still an organic substance, so you should follow safe operating procedures when using and storing it.
-During operation, try to avoid contact with skin and eyes, and wear personal protective equipment when using.
-If contact or ingestion occurs, rinse immediately with plenty of water and seek medical emergency.
- PTSI should be stored in a dry, cool, well-ventilated place, away from fire and oxidizing agents.
-When disposing of waste, it is necessary to follow local regulations and dispose of waste properly to prevent pollution to the environment.
Last Update：2024-04-10 22:29:15
