2-(piperidin-2-yl)piperidine
2,2'-bipiperidyl
CAS: 531-67-9
Molecular Formula: C10H20N2
2-(piperidin-2-yl)piperidine - Names and Identifiers
| Name | 2,2'-bipiperidyl |
| Synonyms | 2,2-bipiperidine 2,2-BIPIPERIDINE 2,2-Bipoperidine 2,2'-bipiperidyl 2,2'-BIPIPERIDINE 1,1'-bipiperidine 1-piperidinopiperidine 1-piperidin-1-ylpiperidine 2-(2-piperidinyl)piperidine 2-(piperidin-2-yl)piperidine 2-(Piperidin-2-yl)piperidine |
| CAS | 531-67-9 |
| EINECS | 208-514-9 |
| InChI | InChI=1/C10H20N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h9-12H,1-8H2 |
| InChIKey | CLBJZAWCBRAMRZ-UHFFFAOYSA-N |
2-(piperidin-2-yl)piperidine - Physico-chemical Properties
| Molecular Formula | C10H20N2 |
| Molar Mass | 168.28 |
| Density | 0.942±0.06 g/cm3(Predicted) |
| Melting Point | 30 °C |
| Boling Point | 93°C/2mmHg(lit.) |
| Flash Point | 126.503°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.017mmHg at 25°C |
| Appearance | powder to lump |
| Color | White to Almost white |
| pKa | 10.78±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.481 |
2-(piperidin-2-yl)piperidine - Introduction
2,2 '-bipiperidyl(2,2'-bipiperidyl) is an organic compound with the formula C10H18N2. Its molecular structure contains two piperidine rings, which are connected at the 2 and 2 'positions respectively. The following is a description of the nature, use, preparation and safety information of 2,2 '-bipiperidyl:
Nature:
-Appearance: 2,2 '-bipiperidyl is a colorless to pale yellow solid.
-Solubility: It is soluble in some organic solvents, such as ethanol, ether and chloroform, but insoluble in water.
-Melting point: Its melting point is about 68-71°C.
Use:
-complex ligand: 2,2 '-bipiperidyl is widely used as a complex ligand in inorganic chemistry. It can form stable complexes with transition metals and is widely used in catalytic reactions, homogeneous and heterogeneous catalysis, etc.
-Drug synthesis: 2,2 '-bipiperidyl is also an important intermediate for the synthesis of some drugs. For example, it can be used as a starting material for the synthesis of imidazole antitumor drugs and β-blockers.
Preparation Method:
- 2,2 '-bipiperidyl can usually be prepared by adding alkylnitrosamines to an alcoholic solution and allowing the reaction to proceed. In this method, nitrosamine gas is distilled from saturated hydrochloric acid into an alcohol solution at a temperature, and the reaction is usually carried out for no more than 24 hours. The resulting reaction mixture was then crystallized under slow heating.
Safety Information:
- 2,2 '-bipiperidyl should be regarded as an organic compound with certain potential harm to human body and environment. When handling or storing, appropriate safety measures must be taken, such as wearing chemical protective gloves, eye and respiratory protection.
-Avoid direct contact with skin, eyes and mucous membranes when handling 2,2 '-bipiperidyl to prevent irritation and inhalation.
-When using 2,2 '-bipiperidyl, please operate in a well-ventilated place to avoid its vapor accumulation.
-Observe local regulations and safe operating procedures when handling or disposing of 2,2 '-bipiperidyl.
Nature:
-Appearance: 2,2 '-bipiperidyl is a colorless to pale yellow solid.
-Solubility: It is soluble in some organic solvents, such as ethanol, ether and chloroform, but insoluble in water.
-Melting point: Its melting point is about 68-71°C.
Use:
-complex ligand: 2,2 '-bipiperidyl is widely used as a complex ligand in inorganic chemistry. It can form stable complexes with transition metals and is widely used in catalytic reactions, homogeneous and heterogeneous catalysis, etc.
-Drug synthesis: 2,2 '-bipiperidyl is also an important intermediate for the synthesis of some drugs. For example, it can be used as a starting material for the synthesis of imidazole antitumor drugs and β-blockers.
Preparation Method:
- 2,2 '-bipiperidyl can usually be prepared by adding alkylnitrosamines to an alcoholic solution and allowing the reaction to proceed. In this method, nitrosamine gas is distilled from saturated hydrochloric acid into an alcohol solution at a temperature, and the reaction is usually carried out for no more than 24 hours. The resulting reaction mixture was then crystallized under slow heating.
Safety Information:
- 2,2 '-bipiperidyl should be regarded as an organic compound with certain potential harm to human body and environment. When handling or storing, appropriate safety measures must be taken, such as wearing chemical protective gloves, eye and respiratory protection.
-Avoid direct contact with skin, eyes and mucous membranes when handling 2,2 '-bipiperidyl to prevent irritation and inhalation.
-When using 2,2 '-bipiperidyl, please operate in a well-ventilated place to avoid its vapor accumulation.
-Observe local regulations and safe operating procedures when handling or disposing of 2,2 '-bipiperidyl.
Last Update：2024-04-09 02:00:47
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