2-(trifluoromethoxy)benzamide

2-(trifluoromethoxy)benzamide - Names and Identifiers

Name	2-(trifluoromethoxy)benzamide
Synonyms	2-(TRIFLUOROMETHOXY)BENZAMIDE 2-(trifluoromethoxy)benzamide Benzamide, 2-(trifluoromethoxy)-
CAS	127979-74-2
InChI	InChI=1/C8H6F3NO2/c9-8(10,11)14-6-4-2-1-3-5(6)7(12)13/h1-4H,(H2,12,13)

2-(trifluoromethoxy)benzamide - Physico-chemical Properties

Molecular Formula	C8H6F3NO2
Molar Mass	205.13
Density	1.381±0.06 g/cm3(Predicted)
Melting Point	153 °C
Boling Point	241.8±40.0 °C(Predicted)
Flash Point	100.1°C
Vapor Presure	0.0351mmHg at 25°C
pKa	15.28±0.50(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.481
MDL	MFCD00042407

2-(trifluoromethoxy)benzamide - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R52 - Harmful to aquatic organisms R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Class	IRRITANT

2-(trifluoromethoxy)benzamide - Introduction

2-(Trifluoromethoxy) benzamide is an organic compound whose chemical formula is C8H6F3NO2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 2-(Trifluoromethoxy) benzamide is a colorless to light yellow solid.
-Solubility: It is soluble in common organic solvents, such as ethanol, toluene and dimethylformamide.
-Melting point: Its melting point is about 65-68°C.

Use:
- 2-(Trifluoromethoxy) benzamide is commonly used in pharmaceutical synthesis, pesticide synthesis and materials science.
-As a reagent, it can be used to remove protecting groups in the synthesis process, such as nucleophilic addition reaction between olefin and alcohol.
-It can also be used as a phase transfer catalyst.

Preparation Method:
- 2-(trifluoromethoxy) benzamide has many preparation methods, and the common method is obtained by the reaction of 2-aminobenzoic acid and trifluoromethanol.

Safety Information:
- 2-(Trifluoromethoxy) benzamide is an organic compound that requires proper disposal.
-Wear appropriate personal protective equipment, such as lab gloves and goggles, to avoid contact with skin and eyes.
-When performing laboratory operations, it needs to be performed in a well-ventilated place to prevent the inhalation of vapor.
-During storage and handling, avoid contact with oxidants and high-temperature substances, and avoid ignition and sparks.
-Since 2-(trifluoromethoxy) benzamide has not been widely studied, data on its toxicity and harmfulness are limited. Care and reference relevant safety information are required when using it.

Last Update：2024-04-09 21:04:16