2-ACETYL-5-METHYLPYRAZINE
1-(6-methylpyridin-3-yl)ethan-1-one
CAS: 36357-38-7
Molecular Formula: C8H9NO
2-ACETYL-5-METHYLPYRAZINE - Names and Identifiers
2-ACETYL-5-METHYLPYRAZINE - Physico-chemical Properties
| Molecular Formula | C8H9NO |
| Molar Mass | 135.16 |
| Density | 1.0168 |
| Melting Point | 17.6°C |
| Boling Point | 55-56°C/Oil Pump |
| Flash Point | 123.418°C |
| Water Solubility | Partly miscible with water. |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.004mmHg at 25°C |
| Appearance | Oil |
| Color | Colourless to Pale Yellow |
| pKa | 4.15±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.5302 (estimate) |
| MDL | MFCD00128113 |
2-ACETYL-5-METHYLPYRAZINE - Risk and Safety
| TSCA | Yes |
2-ACETYL-5-METHYLPYRAZINE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | 5-acetyl-2-methylpyridine is a synthetic treatment of symptoms and signs in the acute and chronic phases of osteoarthritis, as well as the treatment of acute gouty arthritis The intermediate of the drug etoricoxib. Etoricoxib is a selective COX-2 inhibitor with anti-inflammatory, analgesic and antipyretic effects. It has been listed in 84 countries and regions including China. |
| preparation | 150g of 2-methyl-5-ethylpyridine, 420g of tert-butanol and 13g of catalyst N-hydroxysuccinimide are added to a reaction bottle equipped with a stirrer, a thermometer and a dropping funnel. Stirring dissolves 2-methyl-5-ethylpyridine in tert-butanol. When the temperature is raised to 40 ℃, t-butyl hydrogen peroxide will be added dropwise, the reaction system will automatically gradually heat up, control the dropwise acceleration, and maintain the oxidation reaction temperature at 52 ℃ until 111g of t-butyl hydrogen peroxide is added dropwise. The heat preservation reaction was continued at 52 ℃ for 1hr. The reaction ends when the content of 2-methyl -5-ethyl pyridine is less than 0.5%. Recovery of tert-butanol by distillation. 150g of water was added to the system after tert-butanol was recovered, stirred for 30min, and water-soluble substances such as catalyst in the system were dissolved into water. Let stand for 30min, layer and collect oil phase. The oil phase is distilled, the residual water is distilled under reduced pressure, and the distillate under reduced pressure is collected to obtain 158g of product with 98% content (HPLC) and 92.6% yield. |
Last Update：2024-04-09 02:00:08
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Product Name: 5-Acetyl-2-methylpyridine Visit Supplier Webpage Request for quotationCAS: 36357-38-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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