Name | 2-Amino-1,3-propanediol |
Synonyms |
SERINOL Serinol DL-SERINOL 2-AMINO-1,3-PROPANDIOL 2-aminopropane-1,3-diol 2-Amino-1,3-propanediol 2-AMINO-1,3-PROPANEDIOL 2-AMINOPROPANE-1,3-DIOL 1,3-Propanediol, 2-amino- 2-Aminopropan-1,3-propanediol |
CAS | 534-03-2 |
EINECS | 208-584-0 |
InChI | InChI=1/C3H9NO2/c4-3(1-5)2-6/h3,5-6H,1-2,4H2 |
InChIKey | KJJPLEZQSCZCKE-UHFFFAOYSA-N |
Molecular Formula | C3H9NO2 |
Molar Mass | 91.11 |
Density | 1.1278 (rough estimate) |
Melting Point | 52-55 °C (lit.) |
Boling Point | 277 °C (lit.) |
Flash Point | >230°F |
Water Solubility | Soluble in water and alcohol. |
Solubility | DMSO (Soluble, Sonicated), Methanol (Slightly, Sonicated), Water (Slightly) |
Vapor Presure | 0.01Pa at 25℃ |
Appearance | White crystalline powder |
Color | White to off-white |
BRN | 635683 |
pKa | 12.24±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Stability | Hygroscopic |
Sensitive | Hygroscopic |
Refractive Index | 1.4698 (estimate) |
MDL | MFCD00051487 |
Physical and Chemical Properties | Crystallization, moisture absorption. Melting point 52-55 °c, boiling point 115-116 °c, flash point> 110 °c. |
Use | The main raw material of iopamidol |
Risk Codes | 34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 3263 8/PG 2 |
WGK Germany | 1 |
FLUKA BRAND F CODES | 3-10-34 |
TSCA | Yes |
HS Code | 29221990 |
Hazard Note | Corrosive |
Hazard Class | 8 |
Packing Group | III |
LogP | -1.82 at 20℃ |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | serine ammonia alcohol, that is, 2-amino-1, 3-propanediol, is a prochiral amino alcohol. Because its structure is similar to serine, it is usually called serine. Serinol has stable chemical properties, corrosive, hygroscopic and good water solubility. Natural serine was found early in the synthesis of helminthosporin toxin by sugarcane eye spot bacteria. Later, in the process of prokaryotic biosynthesis of rhizobia toxins such as plant pathogens Burkholderia, slow-growing soybean Rhizobium (Bradyrhizobiumjaponicum) and slow-growing Rhizobium elsen (Bradyrhizobiumelkanii), it was also discovered The existence of natural serine. |
Application | Serinol generally exists in the form of a variety of chiral derivatives. Chiral compounds are widely used and occupy an extremely important position in the national economy and people's livelihood; the research, manufacture and use of chiral chemicals are of great significance to environmental protection and human health. Therefore, acylated serine ammonia alcohol and other serine ammonia chiral derivatives have become the focus and hot research recently. Acylated serinol, as an important second messenger in eukaryotes, is involved in regulating and managing various physiological processes such as cell growth, endocytosis, stress response and apoptosis, and plays an important role in the metabolism of eukaryotes. Like other chiral chemicals, serine and its derivatives also have great commercial value, and have more and more extensive applications in medicine, chemical industry and other fields. |
use | serine ammonia alcohol and its derivatives have become a hot topic in the field of organic compound research. Nowadays, serine and its derivatives, as an important intermediate in chemical synthesis, are more widely used in medicine, chemical industry and other fields. An intermediate of iopamidol. It is the main raw material for the synthesis of the drug iopamidol The main raw material for iopamidol (iopamol) |
preparation method | take 2.5g of serine with optical purity above 99.5%, dissolve it with 500g of pure water, and take the pre-prepared preferred but not limited commodity model D201 macroporous anion exchange resin, I .e. 100g of macroporous alkaline anion exchange resin, produced by Langfang new era chemical co., ltd. in Hebei province, China, into the above-mentioned serine aqueous solution, stir for 2.0h (static adsorption), the temperature is controlled at 5-10 ℃, the adsorbed resin is loaded into the column, and the ZnCl2 aqueous solution with a mass percentage concentration of 2% is used for reverse elution. The elution temperature is controlled at 15-20 ℃, and the elution speed is controlled at 5.0-6.0 vvh-1. As the elution progresses, the generated serinol precipitates from the aqueous solution. When there is no solid in the eluate, it contains serinol eluate. After solid-liquid separation, it is dried at 80 ℃ to obtain serinol 3g. Mass yield: 120%. |
Production method | Catalytic hydrogenation of 5-oxime -1, 3-dioxane is reduced to 5-amino-1, 3 dioxane, and then hydrolyzed to obtain the product. |