2-AMINO-4,5-DIFLUOROPHENYLAMINE

2-AMINO-4,5-DIFLUOROPHENYLAMINE - Names and Identifiers

Name	1,2-Diamino-4,5-difluorobenzene
Synonyms	4,5-Difluoro-2-PhenylenediaMin 4,5-Difluoro-o-phenylenediamine 1,2-Diamino-4,5-difluorobenzene 4,5-Difluorobenzene-1,2-diamine 4,5-Difluoro-2-PhenylenediaMine 2-AMINO-4,5-DIFLUOROPHENYLAMINE 4,5-Difluoro-1,2-benzenediamine 4,5-Difluorophenylene-1,2-diamine 4,5-Difluoro-1,2-phenylenediamine
CAS	76179-40-3
EINECS	616-301-0
InChI	InChI=1/C11H13NO3/c13-11(14)9-2-1-3-10(8-9)12-4-6-15-7-5-12/h1-3,8H,4-7H2,(H,13,14)
InChIKey	PPWRHKISAQTCCG-UHFFFAOYSA-N

2-AMINO-4,5-DIFLUOROPHENYLAMINE - Physico-chemical Properties

Molecular Formula	C6H6F2N2
Molar Mass	144.12
Density	1.407±0.06 g/cm3(Predicted)
Melting Point	132 °C
Boling Point	282.2±35.0 °C(Predicted)
Flash Point	208.1°C
Vapor Presure	8.01E-08mmHg at 25°C
Appearance	Crystallization
Color	White to Brown
pKa	3.51±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.579
MDL	MFCD00061131

2-AMINO-4,5-DIFLUOROPHENYLAMINE - Risk and Safety

Safety Description	S24 - Avoid contact with skin. S36/37 - Wear suitable protective clothing and gloves.
HS Code	29215900

2-AMINO-4,5-DIFLUOROPHENYLAMINE - Reference Information

Application

4, 5-difluorobenzene-1, 2-diamine is an intermediate in organic synthesis and chemical and pharmaceutical intermediates, it can be used in the research and development of organic synthesis reaction laboratory and chemical medicine research and development process.

preparation

4, 5-difluoro-2-nitroaniline (10g,57.4mmol),10% Palladium on carbon (1G) and of methanol were mixed together and added to a nitrogen-filled reaction flask. Then 20ml of acetic acid was added and hydrogen was passed through for minutes. The reaction was then allowed to stand at room temperature for 3 days, the Pd catalyst was removed by filtration, the filtrate was collected, and the filtrate was distilled under reduced pressure, and then chloroform was added to dissolve the residue, after repeated extraction with a saturated Na2CO3 solution for 3 times, the organic phase was dried over MgSO4, filtered, the filtrate was collected, and the solvent was distilled off to give a tan solid.

Last Update：2024-04-10 22:29:15