2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE - Names and Identifiers

Name	5-bromo-4-(trifluoromethyl)pyridin-2-amine
Synonyms	2-Amino-5-bromo-4-(trifL 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE 5-Bromo-2-amino-4-trifluoromethylpyridine 5-bromo-4-(trifluoromethyl)pyridin-2-amine 5-bromo-4-(trifluoromethyl)-2-pyridylamine 5-Bromo-4-(trifluoromethyl)-2-pyridinamine 2-amino-5-bromo-4-(trifluoromethyl)pyridine 5-BroMo-4-trifluoroMethyl-pyridin-2-ylaMine 2-Pyridinamine, 5-bromo-4-(trifluoromethyl)-
CAS	944401-56-3
EINECS	693-695-0
InChI	InChI:1S/C6H10BrF3N2/c7-4-2-12-5(11)1-3(4)6(8,9)10/h3-5,12H,1-2,11H2
InChIKey	AEWYLVDLWQPJGW-UHFFFAOYSA-N

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE - Physico-chemical Properties

Molecular Formula	C6H4BrF3N2
Molar Mass	241.01
Density	1.790±0.06 g/cm3(Predicted)
Melting Point	71-74℃
Boling Point	243.9±40.0 °C(Predicted)
Flash Point	101.3 °C
Solubility	Soluble in methanol
Appearance	Solid
Color	Pale yellow to orange
pKa	2.44±0.24(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Use	This product is for scientific research only and shall not be used for other purposes.

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	1
HS Code	29333999
Hazard Class	IRRITANT

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE - Reference Information

Use

5-bromo-4-(trifluoromethyl) pyridin-2-amine can be used as a pharmaceutical synthesis intermediate.

preparation

to 2-amino-4-trifluoromethyl pyridine (10.0g,62.1mmol) in chloroform (ML) to the solution, NBS(12.0g,67.4mmol) was added. The solution was stirred in the dark for 2H at which time it was added to DCM(200ml) and 1n NaOH(200ml). After mixing, the layers were separated and the organic layer was washed with NaCl (saturated)(100ml), dried over Na2SO4, filtered and concentrated. The crude material was purified by Silica Gel chromatography (0-5%EtOAc/CH2Cl2) to give 12.0g(80%) of 5-bromo-4-(trifluoromethyl) pyridin-2-amine: LCMS(m/z):241/243(MH );1H NMR(CDCl3): Δ8.28 (s,1H),6.77(s,1H),4.78(bs,2H).

Last Update：2024-04-10 22:29:15