2-AMino-5-broMobenzoxazole

Name	5-BROMOBENZO[D]OXAZOL-2-AMINE
Synonyms	Nsc24982 EOS-60501 5-Bromo-2-benzoxazolamine 2-AMino-5-broMobenzoxazole 2-amino-5-bromo-benzoxazol 2-Benzoxazolamine, 5-bromo- 5-BROMOBENZO[D]OXAZOL-2-AMINE 5-bromobenzo[b]oxazol-2-amine
CAS	64037-07-6

Use	5-bromobenzene [D] oxazol-2-amine is a heterocyclic derivative and can be used as an intermediate in organic synthesis.
preparation	to 2-amino-4-bromophenol (3)(59.6g,0.317mol) at room temperature A stirred solution in methanol (40.3) was added solid cyanogen bromide (0.38g, 1.2 mol, Eq) in small portions, the resulting mixture was stirred at 35 °c for 6 hours. (Note: cyanogen bromide is highly toxic, reagents and reactions should be carefully disposed of in the fume hood). The reaction mixture was quenched by addition of saturated aqueous Na2CO3 solution and the pH was adjusted to 7-8. Then the mixture was concentrated in vacuo to remove methanol. The residue was dissolved in ethyl acetate (600 mL), washed with water (100mL x 2) and brine (100mL), dried over MgSO4, and filtered. The filtrate was concentrated in vacuo to give the desired product 5-bromobenzene [D] oxazol-2-amine (65.2g,96.5% yield) as a yellow solid.
category	toxic substances
toxicity grade	poisoning
Acute toxicity	poisoning
stimulation data	oral-rat LD50: 1000 mg/kg; Oral-mouse DL50: 819 mg/kg
flammability hazard characteristics	flammability; Toxic NOx and bromide fumes from combustion
storage and transportation characteristics	warehouse ventilation and low temperature drying
extinguishing agent	dry powder, foam, sand, carbon dioxide, water mist