2-AMino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one
2'-C-Methylguanosine
CAS: 374750-30-8
Molecular Formula: C11H15N5O5
2-AMino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one - Names and Identifiers
| Name | 2'-C-Methylguanosine |
| Synonyms | 2-C′-MeG -C-Methylguanosine 2'-C-Methylguanosine 2'-β-C-Methylguanosine 2'-C-β-Methyl Guanosine Guanosine, 2'-C-methyl- 2'-C-beta-Methylguanosine 2-AMino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one |
| CAS | 374750-30-8 |
| InChI | InChI=1/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6?,9-,11-/m1/s1 |
| InChIKey | NVKAMPJSWMHVDK-GITKWUPZSA-N |
2-AMino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one - Physico-chemical Properties
| Molecular Formula | C11H15N5O5 |
| Molar Mass | 297.27 |
| Density | 2.03 |
| Boling Point | 733.1±70.0 °C(Predicted) |
| Solubility | H2O: soluble5mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.31±0.70(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.86 |
2-AMino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one - Risk and Safety
| WGK Germany | 3 |
2-AMino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one - Introduction
2 '-C-Methylguanosine is a derivative of guanosine with the formula C11H15N5O5 and a methyl group added to the 2'-position of guanosine.
2 '-C-Methylguanosine is a white solid, stable to light and soluble in water. In organisms, it is widely used as a component of RNA nucleotides. It has high biocompatibility and stability, so it has a wide range of applications in drug development and biological research.
Its main uses include:
1. Research and development of antiviral drugs: 2 '-C-Methylguanosine, as a nucleotide analog, can inhibit the replication of viral RNA and has antiviral activity against a variety of viruses, such as HIV, hepatitis B virus and hepatitis C virus.
2. RNA research: 2 '-C-Methylguanosine can be used as an important tool to study the structure and function of RNA, and can be used to study the folding dynamics, targeting and stability of RNA.
The preparation of 2 '-C-Methylguanosine is generally achieved by chemical synthesis. Specifically, a precursor of guanosine is first synthesized, and then 2 '-C-Methylguanosine is synthesized by introducing a methyl group at the 2'-position.
Regarding safety information, 2 '-C-Methylguanosine is less toxic and irritating, but it is still necessary to avoid direct contact and inhalation. Use should follow laboratory safety practices and be equipped with appropriate personal protective equipment, such as laboratory gloves and protective glasses. If necessary, follow the relevant waste disposal regulations.
2 '-C-Methylguanosine is a white solid, stable to light and soluble in water. In organisms, it is widely used as a component of RNA nucleotides. It has high biocompatibility and stability, so it has a wide range of applications in drug development and biological research.
Its main uses include:
1. Research and development of antiviral drugs: 2 '-C-Methylguanosine, as a nucleotide analog, can inhibit the replication of viral RNA and has antiviral activity against a variety of viruses, such as HIV, hepatitis B virus and hepatitis C virus.
2. RNA research: 2 '-C-Methylguanosine can be used as an important tool to study the structure and function of RNA, and can be used to study the folding dynamics, targeting and stability of RNA.
The preparation of 2 '-C-Methylguanosine is generally achieved by chemical synthesis. Specifically, a precursor of guanosine is first synthesized, and then 2 '-C-Methylguanosine is synthesized by introducing a methyl group at the 2'-position.
Regarding safety information, 2 '-C-Methylguanosine is less toxic and irritating, but it is still necessary to avoid direct contact and inhalation. Use should follow laboratory safety practices and be equipped with appropriate personal protective equipment, such as laboratory gloves and protective glasses. If necessary, follow the relevant waste disposal regulations.
Last Update：2024-04-09 19:05:49
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