2-Acetylphenothiazine

Name	2-acetyl phenothiazine
Synonyms	ML 171 2-Acetylphenothiazin 2-ACETYLPHENOTHIAZINE NOX1 Inhibitor, ML171 2-Acetylphenothiazine LABOTEST-BB LT00012652 2-Acetyl-phenothiazine 2-acetyl phenothiazine 2-Acetyl-10H-phenothiazine methyl phenothiazin-2-yl ketone 1-(10H-phenothiazin-2-yl)ethanone 1-(10H-Phenothiazin-2-yl)ethan-1- one, 2-Ethanoyl-10H-phenothiazine
CAS	6631-94-3
EINECS	229-626-4
InChI	InChI=1/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3

Molecular Formula	C14H11NOS
Molar Mass	241.31
Density	1.249±0.06 g/cm3(Predicted)
Melting Point	180-185 °C (lit.)
Boling Point	455.7±34.0 °C(Predicted)
Flash Point	229.4°C
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Vapor Presure	1.72E-08mmHg at 25°C
Appearance	Dark yellow-orange powder
Color	Yellow to Dark Orange
Maximum wavelength(λmax)	244nm(MeOH)(lit.)
pKa	-2.45±0.20(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.653
In vitro study	Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC 50 =0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
WGK Germany	3

biological activity	2-Acetylphenothiazine (ML171, 2-APT) is an effective and selective NADPH-oxidase inhibitor with IC50 for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase of 0.25 μM, 5 μM and 3 μM respectively, 5 μM and 5.5 μM.
target	TargetValue NOX1 (HEK293) 0.25 μM NOX3 (HEK293) 3 μM NOX2 (HEK293) 5 μM NOX4 (HEK293) 5 μM xanthine oxidase (HEK293) 5.5 μM
Target	Value
NOX1 (HEK293)	0.25 μM
NOX3 (HEK293)	3 μM
NOX2 (HEK293)	5 μM
NOX4 (HEK293)	5 μM
xanthine oxidase (HEK293)	5.5 μM
in vitro study	Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC 50=0.129 μ m) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation used by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is examined in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.
use	pharmaceutical intermediates for the manufacture of new antipyretic and analgesic drugs, antipyretic and antipyretic propanine and acetazine.

Last Update：2024-04-09 21:31:57

Product Name: 2-Acetylphenothiazine Visit Supplier Webpage Request for quotation
CAS: 6631-94-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: 2-Acetylphenothiazine Visit Supplier Webpage Request for quotation
CAS: 6631-94-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

2-Acetylphenothiazine

2-Acetylphenothiazine Request for Quotation