2-Amino-4-pyridinecarbonitrile
2-Amino-4-cyanopyridine
CAS: 42182-27-4
Molecular Formula: C6H5N3
2-Amino-4-pyridinecarbonitrile - Names and Identifiers
| Name | 2-Amino-4-cyanopyridine |
| Synonyms | 2-Amino-4-cyanopyrid 4-Cyano-2-pyridinamine 5-AMINO-4-CYANOPYRIDINE 2-Amino-4-cyanopyridine 2-AMINO-4-CYANOPYRIDINE 2-Aminoisonicotinonitrile 2-aminopyridine-4-carbonitrile 2-Amino-4-pyridinecarbonitrile 4-PYRIDINECARBONITRILE, 2-AMINO- |
| CAS | 42182-27-4 |
| EINECS | 677-660-7 |
| InChI | InChI=1/C6H5N3/c7-4-5-1-2-9-6(8)3-5/h1-3H,(H2,8,9) |
2-Amino-4-pyridinecarbonitrile - Physico-chemical Properties
| Molecular Formula | C6H5N3 |
| Molar Mass | 119.12 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Melting Point | 146-148°C |
| Boling Point | 297.7±20.0 °C(Predicted) |
| Flash Point | 133.8°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.00133mmHg at 25°C |
| Appearance | White solid |
| BRN | 386393 |
| pKa | 3.93±0.11(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.594 |
| MDL | MFCD03791310 |
2-Amino-4-pyridinecarbonitrile - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. |
| UN IDs | 3439 |
| HS Code | 29333990 |
| Hazard Class | 6.1 |
| Packing Group | III |
2-Amino-4-pyridinecarbonitrile - Reference Information
| use | aminopyridine is an important fine chemical intermediate and is widely used in the fields of medicine and pesticides. 2-Amino-4-cyanopyridine acts as an antagonist of mGluR2 and can be used to treat diseases of the central nervous system. |
| synthesis method | 2-amino -4-cyanopyridine is prepared from 2-aminopyridine through nitrogen oxidation reaction, nitration reaction, amino protection, reduction reaction, Schiman reaction and amino deprotection reaction. This route involves dangerous reactions such as oxidation and nitrification. The synthesis route is long and the yield is low. 2-chloro-4-cyanopyridine can be used as the starting material to prepare the target compound by ammonolysis reaction with ammonia water; 2-nitro-4-cyanopyridine can also be prepared by iron powder reduction. The synthesis reaction formula is as follows: figure 2-amino -4-cyanopyridine synthesis reaction formula |
Last Update：2024-04-09 19:05:03
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