2-Amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide
PKC-iota inhibitor 1
CAS: 2328094-11-5
Molecular Formula: C21H22N6O
2-Amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide - Names and Identifiers
2-Amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide - Physico-chemical Properties
| Molecular Formula | C21H22N6O |
| Molar Mass | 374.44 |
| Density | 1.288±0.06 g/cm3(Predicted) |
| Boling Point | 590.5±50.0 °C(Predicted) |
| pKa | 10.49±0.70(Predicted) |
| Storage Condition | -20°C |
| Use | PKC-iota inhibitor 1 (Compound 19) is a protein kinase C- iota (PKC-ιη) inhibitor with an IC50 value of 0.34 μM. |
2-Amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide - Reference
| Reference Show more | [1]. Kwiatkowski J, et al. Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. |
2-Amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.671 ml | 13.353 ml | 26.707 ml |
| 5 mM | 0.534 ml | 2.671 ml | 5.341 ml |
| 10 mM | 0.267 ml | 1.335 ml | 2.671 ml |
| 5 mM | 0.053 ml | 0.267 ml | 0.534 ml |
Last Update：2024-01-02 23:10:35
