2-Amino-5-chloro-3-methylpyridine

2-Amino-5-chloro-3-methylpyridine - Names and Identifiers

Name	5-chloro-3-methylpyridin-2-amine
Synonyms	NSC508755 NSC 508755 2-AMINO-5-CHLORO-3-PICOLINE 2-Amino-5-Chloro-3-Picoline 5-chloro-3-methylpyridin-2-amine 5-Chloro-3-methyl-2-pyridinamine 2-PyridinaMine,5-chloro-3-Methyl- 2-AMINO-5-CHLORO-3-METHYLPYRIDINE 2-Amino-5-chloro-3-methylpyridine 2-Pyridinamine, 5-chloro-3-methyl- 5-Chloro-3-Methyl-pyridin-2-ylaMine
CAS	20712-16-7
InChI	InChI=1/C6H7ClN2/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3,(H2,8,9)

2-Amino-5-chloro-3-methylpyridine - Physico-chemical Properties

Molecular Formula	C6H7ClN2
Molar Mass	142.59
Density	1.260
Melting Point	56-61°C
Boling Point	254℃
Flash Point	107℃
Vapor Presure	0.0182mmHg at 25°C
pKa	4.98±0.49(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.592
MDL	MFCD00129030

2-Amino-5-chloro-3-methylpyridine - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S39 - Wear eye / face protection.
WGK Germany	3
Hazard Class	IRRITANT

2-Amino-5-chloro-3-methylpyridine - Introduction

It is an organic compound with the chemical formula C7H8ClN. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: It is a white crystalline solid.
-Solubility: Its solubility in water is low, but it can be dissolved in organic solvents (such as ethanol and dimethylformamide).
-Stability: It is relatively stable at room temperature and can be decomposed under light or heating conditions.

Use:
It has a wide range of applications in the field of organic synthesis.
-It can be used as an intermediate for the synthesis of pyridine compounds and other organic compounds.
-In drug synthesis, it is often used as a synthetic raw material for Antibacterial Drugs and antiparasitic drugs.

Method:
It can be prepared by the following reaction:
-First, 3-picoline reacts with sodium chloride in the presence of sodium carbonate to produce 2-methyl-3-chloropyridine.
-Then, 2-methyl -3-chloropyridine reacts with ammonia in a carbonate buffer solution to generate a pyridine.

Safety Information:
-For the use and operation of chemicals, please refer to the Safety Data Sheet (MSDS) and appropriate operating specifications.
-May be irritating to skin, eyes and respiratory tract.
-When using, avoid inhaling aerosols or contact with skin and eyes.
-In the operation, should follow the appropriate safety measures, such as wearing protective gloves, safety glasses and protective masks.

Last Update：2024-04-09 21:01:54