Name | 2-Amino-6,8-dihydroxypurine |
Synonyms | 8-OXOG 8-OXOGUANINE 8-HYDROXYGUANINE 8-Oxodihydroguanine 2-Amino-6,8-purinediol 7,8-DIHYDRO-8-OXOGUANINE 2-Amino-6,8-dihydroxypurine 2-amino-3H-purine-6,8-dione 2-Amino-6-hydroxy-7H-purin-8(9H)-one 2-Amino-8-hydroxy-9H-purine-6(1H)-one 2-amino-7,9-dihydro-3H-purine-6,8-dione 2-Amino-1,6,7,8-tetrahydro-9H-purine-6,8-dione |
CAS | 5614-64-2 |
EINECS | 227-035-6 |
InChI | InChI=1/C5H3N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H3,6,8,9,10,11,12) |
Molecular Formula | C5H5N5O2 |
Molar Mass | 167.13 |
Density | 2.52±0.1 g/cm3(Predicted) |
Melting Point | >400°C dec. |
Boling Point | 327.7°C at 760 mmHg |
Flash Point | 152°C |
Vapor Presure | 0.000199mmHg at 25°C |
pKa | 8.73±0.20(Predicted) |
Refractive Index | 2.156 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
Biological activity | 8-Hydroxyguanine is the main pre-mutagenic damage produced by reactive oxygen species. It leads to G-T and A- C replacement. |
use | 2-Amino-6, 8-dihydroxyurine is an 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase position. |