2-Aminomethyl-3,5-difluoropyridinediHCl

2-Aminomethyl-3,5-difluoropyridinediHCl - Names and Identifiers

Name	2-Aminomethyl-3,5-difluoropyridine dihydrochloride
Synonyms	2-Aminomethyl-3,5-difluoropyridinediHCl 3,5-difluoro-2-MethylaMine (dihydrochloride) 2-Aminomethyl-3,5-difluoropyridine dihydrochloride 5-difluoropyridin-2-yl)MethanaMine dihydrochloride (3,5-Difluoropyridin-2-yl)methylamine dihydrochloride (3,5-difluoropyridin-2-yl)MethanaMine dihydrochloride C-(3,5-Difluoro-pyridin-2-yl)-methylamine dihydrochloride (3,5-Difluoropyridin-2-yl)methylamine dihydrochloride, 3,5-Difluoropicolinylamine dihydrochloride
CAS	1204298-48-5

2-Aminomethyl-3,5-difluoropyridinediHCl - Physico-chemical Properties

Molecular Formula	C6H6F2N2.2HCl
Molar Mass	217
Storage Condition	Inert atmosphere,Room Temperature

2-Aminomethyl-3,5-difluoropyridinediHCl - Reference Information

Use

2-(aminomethyl)-3, 5-difluoropyridine dihydrochloride is 2-(aminomethyl)-3, 5-difluoropyridine hydrochloride, used as a pharmaceutical intermediate.

Preparation

3, 5-difluoropyridinonitrile (23.19mmol) is dissolved in ethanol under stirring, and then concentrated hydrochloric acid aqueous solution (2.6mL) is added. Palladium (10% on carbon) is added under nitrogen, and then the mixture is hydrogenated at 30psi for 2 hours using the Parr apparatus. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure. The residue was divided between EtOAc(40mL) and water (40mL). The water layer was separated, then the pH value was adjusted to 9 with 50% aqueous sodium hydroxide solution (3mL-4mL), and extracted with dichloromethane (3 × 40mL). The combined extract was dried (MgSO4) and concentrated under reduced pressure to obtain light green/brown oil (2.5g,75%). 1H NMR(400MHz,DMSO)8.45(1H,d),7.89-7.84(1H,m),3.82(2H, s),3.33(1H,bs), 1.87(1H,bs).

Last Update：2024-04-09 02:00:01