2-BENZOYLACETANILIDE
Benzoylacetoanilide
CAS: 959-66-0
Molecular Formula: C15H13NO2
2-BENZOYLACETANILIDE - Names and Identifiers
| Name | Benzoylacetoanilide |
| Synonyms | AKOS BBS-00000685 Benzoylacetoanilide 2-Benzoylacetanilide 2-BENZOYLACETANILIDE 2-BENZOYLACETOANILIDE 3-oxo-3-phenylpropionanilide 2-Benzoylacetoanilide(alpha-] 3-oxo-N,3-diphenylpropanamide N,3-Diphenyl-3-oxopropionamide N-Phenyl-β-oxobenzenepropanamide |
| CAS | 959-66-0 |
| EINECS | 213-503-7 |
| InChI | InChI=1/C15H13NO2/c17-14(12-7-3-1-4-8-12)11-15(18)16-13-9-5-2-6-10-13/h1-10H,11H2,(H,16,18) |
| InChIKey | XRZDIHADHZSFBB-UHFFFAOYSA-N |
2-BENZOYLACETANILIDE - Physico-chemical Properties
| Molecular Formula | C15H13NO2 |
| Molar Mass | 239.27 |
| Density | 1.205±0.06 g/cm3(Predicted) |
| Melting Point | 106-108 °C (lit.) |
| Boling Point | 473.6±28.0 °C(Predicted) |
| Flash Point | 194.5°C |
| Solubility | acetone: soluble25mg/mL, clear, colorless to faintly yellow |
| Vapor Presure | 3.9E-09mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 11.37±0.23(Predicted) |
| Refractive Index | 1.624 |
2-BENZOYLACETANILIDE - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 2 |
| RTECS | AB4542950 |
2-BENZOYLACETANILIDE - Reference Information
| properties | acetanilide, also known as N-phenylacetamide, acetamidobenzene, commonly known as cooling ice. Those crystallized from water are orthogonal strains of white scale-like glossy crystals or white crystalline powder. |
| Application | 2-benzoylacetanilide is a very versatile acylating agent in organic synthesis, it can also be used as intermediates and Analytical reagents for pesticides. Although benzoyl acetanilide has applications, but the domestic literature on the synthesis of 2-benzoyl Acetanilide is rarely reported, so the study on the preparation method of 2-benzoyl acetanilide has important industrial application value. |
| Use | Acetanilide can be used as a raw material for veterinary medicine (including fish), for the preparation of intermediate chloroacetanilide and p-aminobenzenesulfonamide, further production of "sulfadimethoxy pyrimidine", "sulfadiazine methoxy pyrimidine", "sulfamethoxyl pyridazine", "sulfathiazole", "sulfamethazine", "sulfamethoxine thiazole" and other drugs. |
| preparation | in a 250mL four-necked flask equipped with a thermometer, add 40g of petroleum ether, 19.2g of ethyl benzoyl acetate, 11.2g of aniline, the catalyst is 0.5g, the condenser tube is installed, and the stirrer is turned on. When the temperature is raised to 120-130 ° C., the ethanol is continuously distilled during the reaction, and the reaction time is 6-12H. After the reaction is finished, filtering is carried out, and the filtered organic phase is cooled to 8-10 ° C., the crystallization is complete, and the benzoyl acetanilide product is obtained by centrifugal filtration. The yield of the product is 94.92%, and the melting point is 107-108 ° C. |
Last Update：2024-04-10 22:29:15
