2-BENZYLBENZIMIDAZOLE,TECH.
bendazol
CAS: 621-72-7
Molecular Formula: C14H12N2
2-BENZYLBENZIMIDAZOLE,TECH. - Names and Identifiers
| Name | bendazol |
| Synonyms | bendazol Bendazol Bendazolo [DCIT] 2-benzyl-benzimidazol 2-Benzylbenzimidazole Bendazolum [INN-Latin] Benzimidazole, 2-benzyl- 2-BENZYLBENZIMIDAZOLE,TECH. 2-(phenylmethyl)-1h-benzimidazol 2-(phenylmethyl)-1h-benzimidazole |
| CAS | 621-72-7 |
| EINECS | 210-703-6 |
| InChI | InChI=1/C14H12N2/c1-2-6-11(7-3-1)10-14-15-12-8-4-5-9-13(12)16-14/h1-9H,10H2,(H,15,16) |
2-BENZYLBENZIMIDAZOLE,TECH. - Physico-chemical Properties
| Molecular Formula | C14H12N2 |
| Molar Mass | 208.26 |
| Density | 1.1345 (rough estimate) |
| Melting Point | 187° |
| Boling Point | 337.46°C (rough estimate) |
| Color | Crystals or needles from benzene |
| pKa | 11.77±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6152 (estimate) |
| Physical and Chemical Properties | Needle-like crystals. Melting Point 187 °c. Practically insoluble in water, soluble in hot benzene, ethanol, glacial acetic acid. Dibazole hydrochloride (C14H12N2. HCI,Dibasol) is a white crystalline powder. Melting Point 175 °c. Soluble in hot water, ethanol, almost insoluble in chloroform, benzene. |
| Use | This product is a smooth muscle relaxant. For hypertension, angina and cerebral vasospasm. Also used for nerve poliomyelitis, peripheral facial paralysis, single neuritis and multiple neuritis. |
2-BENZYLBENZIMIDAZOLE,TECH. - Risk and Safety
| Hazard Class | IRRITANT |
| Toxicity | LD50 orl-mus: 100 mg/kg FRZKAP (1),44,83 |
2-BENZYLBENZIMIDAZOLE,TECH. - Reference Information
| clinical application | dibazol is a kind of antihypertensive drug, its chemical name is 2-benzylbenzimidazole hydrochloride. Dibazol is a white crystalline powder, odorless, melting point is 182-186 ℃, almost insoluble in chloroform and benzene, slightly soluble in hot water or ethanol, almost insoluble in chloroform and benzene. As a smooth muscle relaxant, dibazol tablets have a direct relaxation effect on vascular smooth muscle. They are used to treat hypertension, angina pectoris and cerebral vasospasm. They are also used for neuropoliomyelitis, peripheral facial paralysis, single neuritis and polyneuritis; dibazol eye drops are used to treat pseudomyopia. Dibazol hydrochloride is a smooth muscle relaxant, which is mainly used to treat juvenile pseudomyopia. It can directly relax smooth muscle and expand ciliary anterior artery and venous vessels. It is beneficial to the blood supply of ciliary muscle and improves the nutritional status of ciliary muscle. Dibazol hydrochloride currently on the market is its hydrochloride. | |
| adverse reactions | large doses can cause hyperhidrosis, facial flushing, mild headache, dizziness, nausea and blood pressure drop. | |
| chemical properties | needle crystal. Melting point 187 ℃. Actually insoluble in water, soluble in hot benzene, ethanol, glacial acetic acid. Dibazol hydrochloride (C14H12N2 · HCI,Dibasol) is a white crystalline powder. Melting point 175 ℃. Soluble in hot water, ethanol, almost insoluble in chloroform and benzene. | |
| use | this product is a smooth muscle relaxant. Used for hypertension, angina pectoris and cerebral vasospasm. It is also used for neuropolio, peripheral facial paralysis, mononeuritis and polyneuritis. It has the effects of relaxing blood vessels, lowering blood pressure, relieving smooth muscle spasm and stimulating spinal cord. For hypertension, angina pectoris, pregnancy toxemia, gastrointestinal spasm, polio sequelae and peripheral facial paralysis, etc./td> | |
| production method | o-phenylenediamine and phenylacetic acid are obtained by cyclizing. First, o-phenylenediamine and hydrochloric acid are mixed and heated to dissolve, phenylacetic acid is added, stirred and heated, and dehydrated at 108-110 ℃ for 5 hours. The heating reaction is then heated step by step until the heating is stopped at 240 ℃. Adjust the pH to 9-10 with liquid alkali and filter at 50 ℃ to obtain dibazol. Dibazol is dissolved in water, pH is adjusted to 4.6-4.8 with hydrochloric acid, and activated carbon is added to decolorize dibazol hydrochloride. | |
| category | toxic substances | |
| toxicity classification | highly toxic | |
| acute toxicity | oral administration-mouse LD50: 100 mg/kg; Abdominal cavity-mouse LD50: 240 mg/kg | |
| flammability hazard characteristics | flammability; toxic nitrogen oxide smoke generated by combustion | |
| storage and transportation characteristics | ventilation and low temperature drying; Store separately from warehouse food raw materials | |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-10 22:29:15
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