2-Benzalacetophenone
trans-chalcone
CAS: 614-47-1
Molecular Formula: C15H12O
2-Benzalacetophenone - Names and Identifiers
| Name | trans-chalcone |
| Synonyms | Chalcone trans-chalcone TRANS-CHALCONE 2-BENZALACETOPHENONE PHENYL STYRYL KETONE 3-PHENYLACRYLOPHENONE BENZYLIDENEACETOPHENONE 2-BENZYLIDENEACETOPHENONE 1,3-DIPHENYL-2-PROPEN-1-ONE TRANS-BENZYLIDENEACETOPHENONE (2E)-1,3-diphenylprop-2-en-1-one |
| CAS | 614-47-1 |
| EINECS | 210-383-8 |
| InChI | InChI=1/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+ |
2-Benzalacetophenone - Physico-chemical Properties
| Molecular Formula | C15H12O |
| Molar Mass | 208.26 |
| Density | 1.097g/cm3 |
| Melting Point | 55-57℃ |
| Boling Point | 346.61°C at 760 mmHg |
| Flash Point | 150.062°C |
| Water Solubility | Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water. |
| Solubility | Easily soluble in ether, chloroform, carbon disulfide and benzene, slightly soluble in alcohol, hardly soluble in cold petroleum ether. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Pale yellow powder |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.625 |
| MDL | MFCD00003082 |
| Physical and Chemical Properties | The bioactive trans-Chalcone was isolated from the aronia melanocarpa pericarp and is the bisphenol core structure of the flavonoid precursor. trans-Chalcone are potent fatty acid synthase (FAS) and α-amylase (B> α-amylase) inhibitors. trans-Chalcone caused cell cycle arrest and induced apoptosis in breast cancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activities. |
| Use | Application of trans-chalcone is an unsaturated ketone compound, light yellow rhombohedral prism crystal. It has been reported to be a small molecule GPR52 antagonist. Trans-chalcone can be prepared from a one-step reaction of acetophenone and benzaldehyde. |
2-Benzalacetophenone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | UD5576750 |
| HS Code | 29143990 |
2-Benzalacetophenone - Upstream Downstream Industry
2-Benzalacetophenone - Reference
| Reference Show more | 1. [IF=4.155] Siqi Zhang et al."Step-wise immobilization of multi-enzymes by zirconium-based coordination polymer in situ self-assembly and specific absorption."J Inorg Biochem. 2020 Jul;208:111093 2. [IF=4.57] Liu Jinyue et al."Identification and characterization of unique 5-hydroxyisoflavonoid biosynthetic key enzyme genes in Lupinus albus."Plant Cell Reports. 2021 Dec 01 3. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245 |
2-Benzalacetophenone - Preparation
Under nitrogen, [Ni(dmpymt)2] 6(5 mol%Ni),KOH(1.0 mmol), benzyl alcohol (1.5 mmol) and 1-phenylethanol (1.0 mmol) and toluene (2.5 mL)/ t-BuOH(0.5 mL) were added to a 50 ml Schlenk test tube, the test tube was placed in a 70°C oil bath, and the mixture was stirred in a slow, stable nitrogen stream for 36 hours, cool the mixture to room temperature and add water (10 ml). The aqueous solution was extracted with CH2Cl2(3 × 10 mL), the combined extract was dried with anhydrous Na2SO4, the solvent was removed, and the crude product was purified on short-time rapid column chromatography to obtain trans-chalcone.
Last Update：2024-04-10 22:29:15
2-Benzalacetophenone - Nature
| Merck | 14,2037 |
| BRN | 509985 |
| NIST chemical information | Benzalacetophenone(614-47-1) |
Last Update：2024-04-09 20:52:54
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Raw Materials for 2-Benzalacetophenone
Downstream Products for 2-Benzalacetophenone