| Application | 2-benzyl-5-chloro-1, 2,3, 4-tetrahydro-1, 2,6] naphthyridine can be used as pharmaceutical synthesis intermediates and organic synthesis intermediates, mainly used in laboratory research and development process and chemical medicine synthesis process. |
| preparation | add 6-benzyl -5,6,7, 8-tetrahydro-2 in a round bottom flask, 6-naphthyridin-1-ol (7g, 29 mmol) and phosphoryl chloride {Leonid chemicals, India; 80ml added) were heated to reflux for 16 hours to monitor the progress of the reaction by TLC. After completion of the reaction, POCl3 was distilled and the residue was quenched with ice cold water and then extracted with dichloromethane (3 x 100ml). The combined organic layers were dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography (methanol/dichloromethane, 5:95) to give the desired product, 2-benzyl-5-chloro-1, 2,3, 4-tetrahydro-2, 6] Two azaphthalene (yield 80%). |
