2-Boc-6-hydroxy-2-aza-spi...

Name	tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms	2-Boc-6-hydroxy-2-aza-spi... 2-Boc-6-hydroxy-2-aza-spiro[3.3]heptane 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 6-Hydroxy-2-azaspiro[3.3]heptane, N-BOC protected tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-hydroxy-, 1,1-diMethylethyl ester tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate, 2-(tert-Butoxycarbonyl)-6-hydroxy-2-azaspiro[3.3]heptane
CAS	1147557-97-8

Molecular Formula	C11H19NO3
Molar Mass	213.27
Density	1.17
Melting Point	127-129℃
Boling Point	316.6±42.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	14.84±0.20(Predicted)
Storage Condition	2-8°C
MDL	MFCD15071431

Last Update：2024-01-02 23:10:35

introduction	2,6-diazepam [3.3] heptane has aroused strong interest in the pharmaceutical industry. 2, 6-diazospirl [3.3] heptane has been reported in the 1930s and has become a hot spot in the field of organic synthesis, while 6-hydroxy-2-azospirl [3.3] heptan-2-formate tert-butyl ester is a key intermediate in the synthesis of 2, 6-diazospirl [3.3] heptane.
application	6-hydroxy -2-azamol [3.3] heptane -2-formate tert-butyl ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
preparation	taking epoxy bromide as the starting material, after ring opening, it reacts with ethyl cyanoacetate in a closed loop to produce substituted cyclobutane, and forms azasolo [3.3] heptane with p-toluenesulfonyl chloride. To facilitate separation and purification, the amine was protected by Boc anhydride. Finally, 6-hydroxy-2-azolo [3.3] heptan-2-formic acid tert-butyl ester is generated. Fig. 1 roadmap for synthesis of 6-hydroxy -2-azelo [3.3] heptane -2-formate tert-butyl ester

Last Update：2024-04-09 01:59:59

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CAS: 1147557-97-8
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Product Name: Opnurasib Impurity 4 Request for quotation
CAS: 1147557-97-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Wechat: 18301782025

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2-Boc-6-hydroxy-2-aza-spi...

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