2-Bromo-1H-imidazole
2-Bromo-1H-imidazole
CAS: 16681-56-4
Molecular Formula: C3H3BrN2
2-Bromo-1H-imidazole - Names and Identifiers
| Name | 2-Bromo-1H-imidazole |
| Synonyms | mo-1H-imidazole 2-Bromoimidazole broMo-1H-iMidazole 2-Bromo-1H-imidazole 2-BROMO-1H-IMIDAZOLE 1H-Imidazole, 2-bromo- 1H-Imidazole,2-bromo-(9CI) 2-Bromo-1H-Imidazole(WX637273) |
| CAS | 16681-56-4 |
| InChI | InChI=1/C3H3BrN2/c4-3-5-1-2-6-3/h1-2H,(H,5,6) |
| InChIKey | AXHRGVJWDJDYPO-UHFFFAOYSA-N |
2-Bromo-1H-imidazole - Physico-chemical Properties
| Molecular Formula | C3H3BrN2 |
| Molar Mass | 146.97 |
| Density | 1.904±0.06 g/cm3(Predicted) |
| Melting Point | 197-202 °C |
| Boling Point | 273.1±23.0 °C(Predicted) |
| Flash Point | 118.996°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.006mmHg at 25°C |
| pKa | 11.23±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.602 |
| MDL | MFCD02179526 |
2-Bromo-1H-imidazole - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| HS Code | 29332900 |
| Hazard Note | Harmful/Keep Cold |
2-Bromo-1H-imidazole - Introduction
2-Bromo-1H-imidazole(2-bromo-1H-imidazole) is an organic compound with the chemical formula C3H3BrN2. The following is a description of the nature, use, preparation and safety information of 2-Bromo-1H-imidazole:
Nature:
1. Appearance: 2-Bromo-1H-imidazole is a colorless to slightly yellow crystalline solid.
2. Melting point: Its melting point is about 113-115 degrees Celsius.
3. Solubility: 2-Bromo-1H-imidazole can be dissolved in water and many organic solvents.
Use:
1. Chemical reagent: 2-Bromo-1H-imidazole can be used as a reagent in organic synthesis, such as a catalyst for aryl Bromination and a precursor for imidazole compounds.
2. Drug research: It has important application value in the field of medicine, for the synthesis of antibiotics, anti-tumor drugs and antiviral drugs.
Method:
2-Bromo-1H-imidazole is mainly prepared by the following two methods:
1. Bromination: 1H-imidazole is reacted with bromine, and an appropriate amount of sodium carbonate or silver carbonate is added to catalyze the reaction to form 2-Bromo-1H-imidazole.
2. Bromination: 1H-imidazole reacts with sodium nitrite to generate nitroso-imidazole, and then 2-Bromo-1H-imidazole is obtained through bromination reaction.
Safety Information:
1. 2-Bromo-1H-imidazole has an irritating effect on the eyes, skin and respiratory tract, and should be rinsed with plenty of water immediately after contact.
2. It may decompose at high temperatures to produce harmful gases.
3. When using the need to wear protective glasses and gloves, to ensure that the operation in a well-ventilated laboratory environment.
Please note that the information provided in this reply is for reference only. Please consult relevant literature before use and take appropriate safety protection measures according to the specific situation.
Nature:
1. Appearance: 2-Bromo-1H-imidazole is a colorless to slightly yellow crystalline solid.
2. Melting point: Its melting point is about 113-115 degrees Celsius.
3. Solubility: 2-Bromo-1H-imidazole can be dissolved in water and many organic solvents.
Use:
1. Chemical reagent: 2-Bromo-1H-imidazole can be used as a reagent in organic synthesis, such as a catalyst for aryl Bromination and a precursor for imidazole compounds.
2. Drug research: It has important application value in the field of medicine, for the synthesis of antibiotics, anti-tumor drugs and antiviral drugs.
Method:
2-Bromo-1H-imidazole is mainly prepared by the following two methods:
1. Bromination: 1H-imidazole is reacted with bromine, and an appropriate amount of sodium carbonate or silver carbonate is added to catalyze the reaction to form 2-Bromo-1H-imidazole.
2. Bromination: 1H-imidazole reacts with sodium nitrite to generate nitroso-imidazole, and then 2-Bromo-1H-imidazole is obtained through bromination reaction.
Safety Information:
1. 2-Bromo-1H-imidazole has an irritating effect on the eyes, skin and respiratory tract, and should be rinsed with plenty of water immediately after contact.
2. It may decompose at high temperatures to produce harmful gases.
3. When using the need to wear protective glasses and gloves, to ensure that the operation in a well-ventilated laboratory environment.
Please note that the information provided in this reply is for reference only. Please consult relevant literature before use and take appropriate safety protection measures according to the specific situation.
Last Update：2024-04-09 15:17:53
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