2-Bromo-5-chloro-1,3-difluorobenzene

2-Bromo-5-chloro-1,3-difluorobenzene - Names and Identifiers

Name	2-Bromo-5-chloro-1,3-difluorobenzene
Synonyms	4-Chloro-2,6-difluorobromobenzene 3,5-Difluoro-4-bromo-chlorobenzene 1-Bromo-4-chloro-2,6-difluorobenzene 2-Bromo-5-chloro-1,3-difluorobenzene 4-Bromo-1-chloro-3,5-difluorobenzene Benzene, 2-broMo-5-chloro-1,3-difluoro- Benzene, 2-bromo-5-chloro-1,3-difluoro- 1-Bromo-4-chloro-2,6-difluorobenzene [4-Bromo-3,5-difluorochlorobenzen
CAS	883546-16-5
InChI	InChI=1/C6H2BrClF2/c7-6-4(9)1-3(8)2-5(6)10/h1-2H

2-Bromo-5-chloro-1,3-difluorobenzene - Physico-chemical Properties

Molecular Formula	C6H2BrClF2
Molar Mass	227.43
Density	1.805
Boling Point	176℃
Flash Point	60℃
Vapor Presure	1.53mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.528

2-Bromo-5-chloro-1,3-difluorobenzene - Risk and Safety

Hazard Class

IRRITANT

2-Bromo-5-chloro-1,3-difluorobenzene - Introduction

2-Bromo-5-choro-1, 3-difluorobenzene is an organic compound with the chemical formula C6H2BrClF2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to light yellow crystal or liquid.
-Solubility: Soluble in organic solvents such as ether, methanol and dichloromethane.
-Melting point:-33 ℃
-boiling point: 130~140 ℃
-Density: 1.76g/cm³
-Stability: relatively stable at room temperature, but will react with strong oxidants.

Use:
-2-Bromo-5-choro-1, 3-difluorobenzene is an organic synthesis intermediate, commonly used in the preparation of pesticides, pharmaceuticals and dyes and other compounds.
-In chemical research, it is also often used as a labeling reagent to assist in the identification of compound structures and the study of reaction mechanisms.

Preparation Method:
The preparation of 2-Bromo-5-chloro-1,3-difluorobenzene can be carried out by the following steps:
1. First, p-fluoroborate (C6H3BF2O) or benzylidene boron difluoride (BF2CH2(OMe)) is reacted with benzylidene lithium bromide (C6H5CH2Br) to give 1,3-diphenyl -2,4,5,6-tetrafluorobenzene.
2. Then, 1,3-diphenyl -2,4,5,6-tetrafluorobenzene is reacted with bromine to obtain 2-Bromo-5-chloro-1,3-difluorobenzene.

Safety Information:
2-Bromo-5-chloro-1,3-difluorobenzene has low toxicity, but the following safety measures should be paid attention:
-Wear appropriate personal protective equipment such as gloves, glasses and protective clothing when performing operations.
-Avoid contact with skin and eyes. If you accidentally touch, rinse with plenty of water immediately. If there is an abnormal reaction, seek medical attention as soon as possible.
-Operate in a well-ventilated place and avoid inhaling its vapors.
-Keep sealed during storage and avoid contact with oxidants or flammable substances.

Last Update：2024-04-09 21:01:54