2-Bromo-6-(hydroxymethyl)-3-pyridinol
2-Bromo-6-(hydroxymethyl)-3-pyridinol
CAS: 168015-04-1
Molecular Formula: C6H6BrNO2
2-Bromo-6-(hydroxymethyl)-3-pyridinol - Names and Identifiers
2-Bromo-6-(hydroxymethyl)-3-pyridinol - Physico-chemical Properties
| Molecular Formula | C6H6BrNO2 |
| Molar Mass | 204.02134 |
| Density | 1.836±0.06 g/cm3(Predicted) |
| Melting Point | 127-128° |
| Boling Point | 424.0±40.0 °C(Predicted) |
| pKa | 4.24±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD09702158 |
2-Bromo-6-(hydroxymethyl)-3-pyridinol - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Hazard Class | IRRITANT |
2-Bromo-6-(hydroxymethyl)-3-pyridinol - Introduction
2-Bromo-6-(hydroxymethyl)-3-pyridinol is an organic compound with the chemical formula C7H7BrNO2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 2-Bromo-6-(hydroxymethyl)-3-pyridinol is a white to off-white crystalline solid.
-Solubility: It is slightly soluble in water, soluble in ethanol, ether, chloroform and other organic solvents.
Use:
-Pharmaceutical field: 2-Bromo-6-(hydroxymethyl)-3-pyridinol can be used as a drug intermediate, such as the synthesis of drugs containing pyridine structure.
-Pesticide field: It can also be used to synthesize some pesticide raw materials.
Preparation Method:
2-Bromo-6-(hydroxymethyl)-3-pyridinol synthesis method has a variety of ways, the following is one of the commonly used preparation method:
1. First, 2-amino -6-hydroxymethyl pyridine is reacted with bromoacetic acid to generate 2-hydroxymethyl -6-(hydroxymethyl) pyridine under the catalysis of base.
2. Then, 2-hydroxymethyl -6-(hydroxymethyl) pyridine reacts with hydrochloric acid to generate 2-Bromo-6-(hydroxymethyl)-3-pyridinol under the catalysis of alkali.
Safety Information:
- 2-Bromo-6-(hydroxymethyl)-3-pyridinol has low toxicity, but it is still necessary to pay attention to safe use.
-Wear appropriate protective equipment such as lab gloves, glasses, and lab coats during operation.
-Avoid contact with skin, eyes and respiratory tract. In case of contact, flush immediately with plenty of water and seek medical help.
-When storing, keep away from fire and oxidant, and store in a dry, cool, well-ventilated place.
Nature:
-Appearance: 2-Bromo-6-(hydroxymethyl)-3-pyridinol is a white to off-white crystalline solid.
-Solubility: It is slightly soluble in water, soluble in ethanol, ether, chloroform and other organic solvents.
Use:
-Pharmaceutical field: 2-Bromo-6-(hydroxymethyl)-3-pyridinol can be used as a drug intermediate, such as the synthesis of drugs containing pyridine structure.
-Pesticide field: It can also be used to synthesize some pesticide raw materials.
Preparation Method:
2-Bromo-6-(hydroxymethyl)-3-pyridinol synthesis method has a variety of ways, the following is one of the commonly used preparation method:
1. First, 2-amino -6-hydroxymethyl pyridine is reacted with bromoacetic acid to generate 2-hydroxymethyl -6-(hydroxymethyl) pyridine under the catalysis of base.
2. Then, 2-hydroxymethyl -6-(hydroxymethyl) pyridine reacts with hydrochloric acid to generate 2-Bromo-6-(hydroxymethyl)-3-pyridinol under the catalysis of alkali.
Safety Information:
- 2-Bromo-6-(hydroxymethyl)-3-pyridinol has low toxicity, but it is still necessary to pay attention to safe use.
-Wear appropriate protective equipment such as lab gloves, glasses, and lab coats during operation.
-Avoid contact with skin, eyes and respiratory tract. In case of contact, flush immediately with plenty of water and seek medical help.
-When storing, keep away from fire and oxidant, and store in a dry, cool, well-ventilated place.
Last Update：2024-04-09 21:01:54
