2-Bromo-6-(trifluoromethyl)pyridine

2-Bromo-6-(trifluoromethyl)pyridine - Names and Identifiers

Name	2-bromo-6-(trifluoromethyl)pyridine
Synonyms	2-Bromo-6-(t 2-Bromo-6-trifluoronethylpyridine 2-Bromo-6-trifluoromethylpyridine 2-TRIFLUOROMETHYL-6-BROMOPYRIDINE 2-bromo-6-(trifluoromethyl)pyridine 2-Bromo-6-(trifluoromethyl)pyridine 2-BROMO-6-(TRIFLUOROMETHYL)PYRIDINE 6-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE 2-Bromo-6-(trifuluoromethyl)pyridine 6-Bromo-alpha,alpha,alpha-trifluoro-2-picoline
CAS	189278-27-1
InChI	InChI=1/C6H3BrF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H
InChIKey	DOWNSQADAFSSAR-UHFFFAOYSA-N

2-Bromo-6-(trifluoromethyl)pyridine - Physico-chemical Properties

Molecular Formula	C6H3BrF3N
Molar Mass	225.99
Density	1.707±0.06 g/cm3(Predicted)
Melting Point	48-52°C
Boling Point	78-79°C 14mm
Flash Point	78-79°C/14mm
Vapor Presure	1.93mmHg at 25°C
pKa	-3.89±0.12(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.471
MDL	MFCD00153087

2-Bromo-6-(trifluoromethyl)pyridine - Risk and Safety

Risk Codes	R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
HS Code	29333990
Hazard Class	IRRITANT
Packing Group	Ⅲ

2-Bromo-6-(trifluoromethyl)pyridine - Reference Information

Application

2-bromo-6-trifluoromethylpyridine is a pyridine compound. Pyridine is the most widely used nitrogen-containing heterocyclic ring. Its chemical properties are very active and are widely used in medicine, pesticides, dyes, rubber and other fields.

preparation

preparation of 2-hydrazinyl -6-trifluoromethylpyridine: add 14.5g of 40% hydrazine hydrate and 10ml of isopropanol in a 100ml single-mouth bottle, slowly drop 7g 2-chloro -6-trifluoromethylpyridine into the mixed solution at room temperature, after dropping, the temperature is raised until reflux is stirred for 1h. After cooling, the reaction solution is poured into water, extracted with ethyl acetate, organic phases are combined, anhydrous sodium sulfate is dried, and the solvent is evaporated to obtain 6.5g of white solid. Preparation of 2-bromo-6-trifluoromethylpyridine: 5g2-hydrazin-6-trifluoromethylpyridine and 50ml chloroform were added to a 100ml three-mouth bottle, 2.89ml bromine was added dropwise at room temperature, and then rose to reflux and stirred for 1h after dripping. After cooling, pour the reaction solution into water, add 10ml of saturated sodium thiosulfate solution, adjust pH = 8 with saturated sodium carbonate solution, extract with ethyl acetate, combine organic phases, dry with anhydrous sodium sulfate, and evaporate the solvent to obtain 5.57g of white solid.

Last Update：2024-04-10 22:29:15