2-Bromo-6-Fluoro-4-Picoline
2-Bromo-6-Fluoro-4-Picoline
CAS: 180608-37-1
Molecular Formula: C6H5BrFN
2-Bromo-6-Fluoro-4-Picoline - Names and Identifiers
| Name | 2-Bromo-6-Fluoro-4-Picoline |
| Synonyms | 2-Bromo-6-Fluoro-4-Picoline 2-Bromo-6-fluoro-4-methylpyridine Pyridine,2-broMo-6-fluoro-4-Methyl- |
| CAS | 180608-37-1 |
| InChI | InChI=1/C6H5BrFN/c1-4-2-5(7)9-6(8)3-4/h2-3H,1H3 |
2-Bromo-6-Fluoro-4-Picoline - Physico-chemical Properties
| Molecular Formula | C6H5BrFN |
| Molar Mass | 190.01 |
| Density | 1.592 |
| Boling Point | 231℃ |
| Flash Point | 93℃ |
| Water Solubility | Slightly soluble in water. |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| pKa | -4.22±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.53 |
2-Bromo-6-Fluoro-4-Picoline - Introduction
The chemical formula is C6H5BrF, which is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
It is a solid crystal with a white or off-white color. It has a unique aroma. It is a pyridine compound having halogen and fluoro substituents.
Use:
The compound has certain application value in the field of medicine. It can be used as an intermediate in the synthesis of other complex compounds, for example in the preparation of pharmaceuticals, pesticides and other active organic compounds.
Method:
can be prepared by the reaction of pyridine with methyl bromide and hydrogen fluoride. The specific reaction steps are as follows:
1. Pyridine is added to an appropriate reaction solvent.
2. Slowly add methyl bromide.
3. Hydrogen fluoride was added as a catalyst.
4. Control the reaction temperature and reaction time.
5. Filtration and crystallization to obtain crystals of quartz.
Safety Information:
In the handling of the need to pay attention to safety precautions. It is an irritating substance that may cause irritation to the eyes, skin and respiratory system. Therefore, appropriate protective gloves, glasses and respirators should be worn during contact. At the same time, in the operation should avoid inhalation of its gas and dust, to maintain a well-ventilated laboratory environment. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
Nature:
It is a solid crystal with a white or off-white color. It has a unique aroma. It is a pyridine compound having halogen and fluoro substituents.
Use:
The compound has certain application value in the field of medicine. It can be used as an intermediate in the synthesis of other complex compounds, for example in the preparation of pharmaceuticals, pesticides and other active organic compounds.
Method:
can be prepared by the reaction of pyridine with methyl bromide and hydrogen fluoride. The specific reaction steps are as follows:
1. Pyridine is added to an appropriate reaction solvent.
2. Slowly add methyl bromide.
3. Hydrogen fluoride was added as a catalyst.
4. Control the reaction temperature and reaction time.
5. Filtration and crystallization to obtain crystals of quartz.
Safety Information:
In the handling of the need to pay attention to safety precautions. It is an irritating substance that may cause irritation to the eyes, skin and respiratory system. Therefore, appropriate protective gloves, glasses and respirators should be worn during contact. At the same time, in the operation should avoid inhalation of its gas and dust, to maintain a well-ventilated laboratory environment. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:11:58
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