2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID
2-Chloro-3-fluoropyridine-4-carboxylic acid
CAS: 628691-93-0
Molecular Formula: C6H3ClFNO2
2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID - Names and Identifiers
2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID - Physico-chemical Properties
| Molecular Formula | C6H3ClFNO2 |
| Molar Mass | 175.54 |
| Density | 1.576±0.06 g/cm3(Predicted) |
| Melting Point | 199°C (dec.) |
| Boling Point | 389.1±37.0 °C(Predicted) |
| Flash Point | 118.6°C |
| Vapor Presure | 0.00604mmHg at 25°C |
| pKa | 2.07±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.542 |
| MDL | MFCD04038325 |
2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID - Reference Information
| introduction | 2-chloro-3-fluoro-isonicotinic acid is an organic intermediate, which can be prepared from 2-chloro-3-fluoropyridine by reaction with strong alkali and dry ice. |
| use | 2-chloro -3-fluoro-isonicotinic acid is a carboxylic acid organic substance, and it has been reported in the literature that it can be used to prepare ADP receptor antagonist antiplatelet drugs. |
| preparation | n-butyl lithium (290ml,0.72mol) is added to diisopropylamine (95ml,0.66mol) in a solution of 500ml anhydrous THF under nitrogen at -78 ℃. After stirring for 0.5 hours, the resulting mixture was added to a solution of 2-chloro-3-fluoropyridine (78g,0.60mmol) in 200ml of anhydrous THF at -78°C. after stirring for 3 hours, pour the mixture into dry ice (340g,6.0mol). Dilute the mixture with water (1L) and adjust the pH to about 2 with 2M aqueous hydrochloric acid. The product was extracted with ethyl acetate (3 × 500mL), and the combined extract was washed with brine, dried with Na2SO4, filtered and concentrated, and the solid residue was recrystallized from EtOAc to give the title compound. |
Last Update：2024-04-09 21:01:54
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View History
2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID
C.I. Pigment Black 11
21205-24-3
N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
TANTALUM PENTA-N-BUTOXIDE
7-[3-[4-Benzyl-1-piperazinyl]propyloxy]-4H-1-benzopyran-4-one
Curcuma oil
4ml超滤离心管10KDa
Bensulfuron-methyl Solution
4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one
C.I. Pigment Black 11
21205-24-3
N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
TANTALUM PENTA-N-BUTOXIDE
7-[3-[4-Benzyl-1-piperazinyl]propyloxy]-4H-1-benzopyran-4-one
Curcuma oil
4ml超滤离心管10KDa
Bensulfuron-methyl Solution
4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one