4-chloro-2-nitro-6-(trifluoromethyl)aniline
2-Chloro-3-fluoropyridine-4-carboxylic acid
CAS: 628691-93-0
Molecular Formula: C6H3ClFNO2
4-chloro-2-nitro-6-(trifluoromethyl)aniline - Names and Identifiers
4-chloro-2-nitro-6-(trifluoromethyl)aniline - Physico-chemical Properties
| Molecular Formula | C6H3ClFNO2 |
| Molar Mass | 175.54 |
| Density | 1.576±0.06 g/cm3(Predicted) |
| Melting Point | 199°C (dec.) |
| Boling Point | 389.1±37.0 °C(Predicted) |
| Flash Point | 118.6°C |
| Vapor Presure | 0.00604mmHg at 25°C |
| pKa | 2.07±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.542 |
| MDL | MFCD04038325 |
4-chloro-2-nitro-6-(trifluoromethyl)aniline - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
4-chloro-2-nitro-6-(trifluoromethyl)aniline - Reference Information
| introduction | 2-chloro-3-fluoro-isonicotinic acid is an organic intermediate, which can be prepared from 2-chloro-3-fluoropyridine by reaction with strong alkali and dry ice. |
| use | 2-chloro -3-fluoro-isonicotinic acid is a carboxylic acid organic substance, and it has been reported in the literature that it can be used to prepare ADP receptor antagonist antiplatelet drugs. |
| preparation | n-butyl lithium (290ml,0.72mol) is added to diisopropylamine (95ml,0.66mol) in a solution of 500ml anhydrous THF under nitrogen at -78 ℃. After stirring for 0.5 hours, the resulting mixture was added to a solution of 2-chloro-3-fluoropyridine (78g,0.60mmol) in 200ml of anhydrous THF at -78°C. after stirring for 3 hours, pour the mixture into dry ice (340g,6.0mol). Dilute the mixture with water (1L) and adjust the pH to about 2 with 2M aqueous hydrochloric acid. The product was extracted with ethyl acetate (3 × 500mL), and the combined extract was washed with brine, dried with Na2SO4, filtered and concentrated, and the solid residue was recrystallized from EtOAc to give the title compound. |
Last Update：2024-04-09 21:01:54
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View History
4-chloro-2-nitro-6-(trifluoromethyl)aniline
1H-吡咯并[2,3-B]吡啶-3-甲酸甲酯
BAS 01045023
CHLOROHEXIDINE DIGLUCONATE, SOLUTION
雌二醇杂质M
4-(2-Formylphenyl)Piperazine-1-Carboxylic Acid Tert-Butyl Ester
Isopropylphenyl phosphate
Carbamic acid, [2-[6-[(methylamino)carbonyl]-1,3-benzodioxol-5-yl]phenyl]-, 1,1-dimethylethyl ester (9CI)
51285-13-3
Benz[a]anthracene-7-acetic Acid Methyl Ester
1H-吡咯并[2,3-B]吡啶-3-甲酸甲酯
BAS 01045023
CHLOROHEXIDINE DIGLUCONATE, SOLUTION
雌二醇杂质M
4-(2-Formylphenyl)Piperazine-1-Carboxylic Acid Tert-Butyl Ester
Isopropylphenyl phosphate
Carbamic acid, [2-[6-[(methylamino)carbonyl]-1,3-benzodioxol-5-yl]phenyl]-, 1,1-dimethylethyl ester (9CI)
51285-13-3
Benz[a]anthracene-7-acetic Acid Methyl Ester