2-CHLORO-4-IODOPYRIDINE
2-Chloro-4-iodopyridine
CAS: 153034-86-7
Molecular Formula: C5H3ClIN
2-CHLORO-4-IODOPYRIDINE - Names and Identifiers
| Name | 2-Chloro-4-iodopyridine |
| Synonyms | 2-Chloro-4-iodopyrid 2-CHLORO-IODOPYRIDINE 4-Iodo-2-chloropyridine 2-Chloro-4-iodopyridine 2-CHLORO-4-IODOPYRIDINE Pyridine, 2-chloro-4-iodo- |
| CAS | 153034-86-7 |
| EINECS | 628-020-0 |
| InChI | InChI=1/C5H3ClIN/c6-5-3-4(7)1-2-8-5/h1-3H |
2-CHLORO-4-IODOPYRIDINE - Physico-chemical Properties
| Molecular Formula | C5H3ClIN |
| Molar Mass | 239.44 |
| Density | 2.052±0.06 g/cm3(Predicted) |
| Melting Point | 42-43 °C (lit.) |
| Boling Point | 255.5±20.0 °C(Predicted) |
| Flash Point | 110°C |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | 0.026mmHg at 25°C |
| Appearance | White-like crystal |
| Color | White to yellow |
| BRN | 108668 |
| pKa | -0.03±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.642 |
| MDL | MFCD01861983 |
2-CHLORO-4-IODOPYRIDINE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R43 - May cause sensitization by skin contact R36/37/38 - Irritating to eyes, respiratory system and skin. R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. |
| UN IDs | UN2811 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Note | Irritant/Light Sensitive |
| Hazard Class | IRRITANT |
2-CHLORO-4-IODOPYRIDINE - Introduction
2-Chloro-4-iodopyridine is an organic compound with the chemical formula C5H2ClIN. The following is an introduction to its nature, use, preparation and safety information:
Nature:
2-Chloro-4-iodopyridine is a colorless to light yellow crystal with a pyridine-like aroma. It is stable at room temperature, soluble in organic solvents such as alcohols, ethers and ketones, and slightly soluble in water. It has a melting point of 118-120°C and a boiling point of about 310°C.
Use:
2-Chloro-4-iodopyridine is widely used in the field of organic synthesis, mainly for the synthesis of pharmaceutical intermediates, pesticides and dyes and other compounds. It can also be used as a reagent in organic chemical reactions, for example for catalyzing or participating in substitution and cyclization reactions.
Method:
2-Chloro-4-iodopyridine has a variety of preparation methods, and the commonly used method is obtained by the reaction of 2-bromo-4-nitropyridine with cuprous chloride. The specific step is to first react 2-bromo-4-nitropyridine with cuprous chloride under alkaline conditions, and then obtain 2-Chloro-4-iodopyridine by reducing and adjusting the reaction conditions.
Safety Information:
1.2-Chloro-4-iodopyridine has a certain corrosive, avoid contact with skin and eyes.
2. In the operation should take a good ventilation system, avoid inhalation of its vapor.
3. Storage should be away from fire and oxidant, stored in a cool, dry, ventilated place.
4. Please carefully read and follow the chemical storage and disposal specifications of the product before use.
5. When used in laboratory or industrial production, please follow relevant safety procedures and wear appropriate personal protective equipment.
Nature:
2-Chloro-4-iodopyridine is a colorless to light yellow crystal with a pyridine-like aroma. It is stable at room temperature, soluble in organic solvents such as alcohols, ethers and ketones, and slightly soluble in water. It has a melting point of 118-120°C and a boiling point of about 310°C.
Use:
2-Chloro-4-iodopyridine is widely used in the field of organic synthesis, mainly for the synthesis of pharmaceutical intermediates, pesticides and dyes and other compounds. It can also be used as a reagent in organic chemical reactions, for example for catalyzing or participating in substitution and cyclization reactions.
Method:
2-Chloro-4-iodopyridine has a variety of preparation methods, and the commonly used method is obtained by the reaction of 2-bromo-4-nitropyridine with cuprous chloride. The specific step is to first react 2-bromo-4-nitropyridine with cuprous chloride under alkaline conditions, and then obtain 2-Chloro-4-iodopyridine by reducing and adjusting the reaction conditions.
Safety Information:
1.2-Chloro-4-iodopyridine has a certain corrosive, avoid contact with skin and eyes.
2. In the operation should take a good ventilation system, avoid inhalation of its vapor.
3. Storage should be away from fire and oxidant, stored in a cool, dry, ventilated place.
4. Please carefully read and follow the chemical storage and disposal specifications of the product before use.
5. When used in laboratory or industrial production, please follow relevant safety procedures and wear appropriate personal protective equipment.
Last Update：2024-04-09 02:00:42
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