2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE
3-Amino-2-chloro-4-methyl pyridine
CAS: 133627-45-9
Molecular Formula: C6H7ClN2
2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE - Names and Identifiers
| Name | 3-Amino-2-chloro-4-methyl pyridine |
| Synonyms | TIMTEC-BB SBB010194 ASINEX-REAG BAS 13794917 2-CHLORO-3-AMINO-4-PICOLINE 3-AMINO-2-CHLORO-4-PICOLINE 3-chloro-2-methylpyridin-4-amine 2-CHLORO-4-METHYLPYRIDIN-3-AMINE 2-chloro-4-methylpyridin-3-amine 2-chloro-3-amino-4-methylpyridine 2-CHLORO-3-AMINO-4-METHYLPYRIDINE 3-amino-2-chloro-4-methylpyridine 2-Chloro-3-amino-4-methyl pyridine 3-Amino-2-chloro-4-methyl pyridine 2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE 2-Chloro-3-Amino-4-Methylpyridine,Nevirapine |
| CAS | 133627-45-9 |
| EINECS | 603-756-5 |
| InChI | InChI=1/C6H7ClN2/c1-4-6(7)5(8)2-3-9-4/h2-3H,1H3,(H2,8,9) |
| InChIKey | UOBCYTOUXLAABU-UHFFFAOYSA-N |
2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE - Physico-chemical Properties
| Molecular Formula | C6H7ClN2 |
| Molar Mass | 142.59 |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Melting Point | 65-70 °C |
| Boling Point | 283.3±35.0 °C(Predicted) |
| Flash Point | 104.7°C |
| Solubility | Chloroform, Ethanol |
| Vapor Presure | 0.0229mmHg at 25°C |
| Appearance | White-like crystal |
| Color | Off White |
| pKa | 3.22±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.592 |
| MDL | MFCD00673152 |
| Physical and Chemical Properties | Melting Point 61-64°C |
| Use | Is an important intermediate in the synthesis of the anti-HIV and HIV-preventive drug navelapine |
2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. |
| UN IDs | UN2811 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE - Reference Information
| introduction | 2-chloro-3-amino-4-methylpyridine is a key intermediate of the anti-AIDS drug nevirapine (Nevirapine). Nevirapine, chemical name 11-cyclopropyl -5,11-dihydro-4-methyl-6H-dipyridino [1,4] diazepine -6-one, is a non-nucleoside HIV reversal enzyme inhibitor (NNRTIs) developed by the German BoehringerIngelheim Company in the early 2090 s, which can treat adult HIV-infected and AIDS patients alone or in combination with drugs, it can effectively resist human immunodeficiency virus -1(HIV-1), mainly to prevent HIV replication, is currently one of the most widely used anti-AIDS drugs, mainly used to prevent mother-to-child virus transmission. |
| application | 2-chloro-3-amino-4-methylpyridine is a key pharmaceutical intermediate for the synthesis of anti-AIDS drug nevirapine, which is widely used in medicine, In the synthesis and development of pesticides and veterinary drugs, it has high application value and market value. |
| Preparation | Using 2-hydroxy-3-nitro-4-methylpyridine as raw material, it is chlorinated and reduced to obtain 2-chloro-3-amino-4-methylpyridine. |
| use | is an important intermediate for the synthesis of the anti-HIV and HIV prevention drug nabvirapine |
Last Update：2024-04-09 02:00:06
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