2-CHLORO-5-FLUOROPYPRIDINE
2-Chloro-5-fluoropyridine
CAS: 31301-51-6
Molecular Formula: C5H3ClFN
2-CHLORO-5-FLUOROPYPRIDINE - Names and Identifiers
| Name | 2-Chloro-5-fluoropyridine |
| Synonyms | 5-Fluoro-2-chloropyridine 2-Chloro-5-fluoropyridine 2-CHLORO-5-FLUOROPYRIDINE 2-chloro-5-fluoro pyridine 2-CHLORO-5-FLUOROPYPRIDINE 2-chloro-5-fluoridepyridine Pyridine, 2-chloro-5-fluoro- Benzoic acid, 2-amino-3-(trifluoromethyl)- |
| CAS | 31301-51-6 |
| InChI | InChI=1/C8H6F3NO2/c9-8(10,11)5-3-1-2-4(6(5)12)7(13)14/h1-3H,12H2,(H,13,14) |
| InChIKey | QOGXQLSFJCIDNY-UHFFFAOYSA-N |
2-CHLORO-5-FLUOROPYPRIDINE - Physico-chemical Properties
| Molecular Formula | C5H3ClFN |
| Molar Mass | 131.54 |
| Density | 1.297 g/mL at 25 °C |
| Melting Point | 19℃ |
| Boling Point | 74 °C / 38mmHg |
| Flash Point | 108°C |
| Vapor Presure | 0.000629mmHg at 25°C |
| Appearance | powder to lump to clear liquid |
| Color | White or Colorless to Light yellow |
| pKa | -2.20±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | n20/D 1.503 |
| Physical and Chemical Properties | Colorless transparent liquid |
2-CHLORO-5-FLUOROPYPRIDINE - Risk and Safety
| Risk Codes | R10 - Flammable R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | III |
2-CHLORO-5-FLUOROPYPRIDINE - Introduction
2-Chloro-5-fluoropyridine is an organic compound with the chemical formula C5H3ClFN. It is a colorless to light yellow liquid with a special smell.
2-Chloro-5-fluoropyridine is often used as an important intermediate in organic synthesis. It can be used to synthesize various compounds such as drugs, pesticides and dyes. For example, it can be used to prepare compounds with anti-tumor activity.
The preparation method of 2-Chloro-5-fluoropyridine is usually obtained by reacting 2-chloropyridine with hydrofluoric acid and ammonium hydrofluoric acid. The reaction conditions are generally carried out at an appropriate temperature and an acid catalyst is used to promote the reaction.
Safety precautions should be taken when using and handling 2-Chloro-5-fluoropyridine. It is a flammable liquid and should be stored in a cool, well-ventilated place. Rinse with plenty of water immediately after contact with skin and eyes. Wear appropriate protective equipment such as gloves, goggles and protective clothing during operation. At the same time, the relevant operating procedures and safety measures should be followed to ensure safe use. In case of misuse or inhalation, seek medical attention immediately.
2-Chloro-5-fluoropyridine is often used as an important intermediate in organic synthesis. It can be used to synthesize various compounds such as drugs, pesticides and dyes. For example, it can be used to prepare compounds with anti-tumor activity.
The preparation method of 2-Chloro-5-fluoropyridine is usually obtained by reacting 2-chloropyridine with hydrofluoric acid and ammonium hydrofluoric acid. The reaction conditions are generally carried out at an appropriate temperature and an acid catalyst is used to promote the reaction.
Safety precautions should be taken when using and handling 2-Chloro-5-fluoropyridine. It is a flammable liquid and should be stored in a cool, well-ventilated place. Rinse with plenty of water immediately after contact with skin and eyes. Wear appropriate protective equipment such as gloves, goggles and protective clothing during operation. At the same time, the relevant operating procedures and safety measures should be followed to ensure safe use. In case of misuse or inhalation, seek medical attention immediately.
Last Update：2024-04-09 21:11:58
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CAS: 31301-51-6
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