2-Carbonitrile-6-trifluoromethylpyridine

2-Carbonitrile-6-trifluoromethylpyridine - Names and Identifiers

Name	6-(trifluoromethyl)pyridine-2-carbonitrile
Synonyms	LogP 2-Cyano-6-trifluoromethylpyridine 6-(trifluoromethyl)picolinonitrile 2-Carbonitrile-6-trifluoromethylpyridine 6-(Trifluoromethyl)pyridine-2-carbonitrile 6-(trifluoromethyl)pyridine-2-carbonitrile 6-(TrifluoroMethyl)-2-pyridinecarbonitrile 2-pyridinecarbonitrile, 6-(trifluoromethyl)- 2-Pyridinecarbonitrile, 6-(trifluoromethyl)-
CAS	887583-52-0
InChI	InChI=1/C7H3F3N2/c8-7(9,10)6-3-1-2-5(4-11)12-6/h1-3H

2-Carbonitrile-6-trifluoromethylpyridine - Physico-chemical Properties

Molecular Formula	C7H3F3N2
Molar Mass	172.11
Density	1.37±0.1 g/cm3(Predicted)
Boling Point	208.6±35.0 °C(Predicted)
Flash Point	80°C
Vapor Presure	0.212mmHg at 25°C
pKa	-5.00±0.12(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.456

2-Carbonitrile-6-trifluoromethylpyridine - Introduction

6-(trifluoromethyl)pyridine-2-carbonitrile is an organic compound with the chemical formula C7H3F3N. It has a molecular weight of about 161.1g/mol. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless or light yellow solid
-Melting point: 77-78°C
-Boiling Point: 148-149°C
-Density: 1.44g/cm³
-Stability: Stable at room temperature, but can decompose or burn
-Solubility: Soluble in organic solvents such as ethanol, ether and dimethylformamide

Use:
- 6-(trifluoromethyl)pyridine-2-carbonitrile is often used as an intermediate in organic synthesis. Its trifluoromethyl group plays an important role in a variety of reactions, such as providing electrophiles for chemical reactions in organic synthesis.
-It can also be used as a raw material for certain insecticides and pesticides.

Preparation Method:
The preparation of 6-(trifluoromethyl)pyridine-2-carbonitrile usually takes the following steps:
1. Reaction: 2-pyridinethanone and trifluoromethylmagnesium iodide (also known as Jilin reagent) are reacted in a reaction solvent to generate 6-trifluoromethylpyridine lithium salt.
2. Cyanation: The lithium salt reacts with hydrocyanic acid to generate 6-(trifluoromethyl)pyridine-2-carbonitrile.

Safety Information:
- 6-(trifluoromethyl)pyridine-2-carbonitrile is an organic compound with certain toxicity. Use should pay attention to comply with laboratory safety procedures.
-When in contact with skin and eyes, rinse immediately with plenty of water. If you have serious discomfort, you should seek medical treatment.
-It should be kept away from high temperatures, open flames and oxidants, and stored in a dry, well-ventilated place.
-For the environment, 6-(trifluoromethyl)pyridine-2-carbonitrile may be toxic to aquatic organisms, so it should be avoided from being discharged into water bodies.

Last Update：2024-04-10 22:29:15